1k0n: Difference between revisions

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-[[Image:1k0n.png|left|200px]]
-<!--
+==Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione==
-The line below this paragraph, containing "STRUCTURE_1k0n", creates the "Structure Box" on the page.
+<StructureSection load='1k0n' size='340' side='right'caption='[[1k0n]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1k0n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K0N FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
-{{STRUCTURE_1k0n|  PDB=1k0n  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k0n OCA], [https://pdbe.org/1k0n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k0n RCSB], [https://www.ebi.ac.uk/pdbsum/1k0n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k0n ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k0/1k0n_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k0n ConSurf].
+<div style="clear:both"></div>
-===Chloride Intracellular Channel 1 (CLIC1) complexed with glutathione===
+==See Also==
+*[[Ion channels 3D structures|Ion channels 3D structures]]
+== References ==
-<!--
+<references/>
-The line below this paragraph, {{ABSTRACT_PUBMED_11551966}}, adds the Publication Abstract to the page
+__TOC__
-(as it appears on PubMed at http://www.pubmed.gov), where 11551966 is the PubMed ID number.
+</StructureSection>
--->
-{{ABSTRACT_PUBMED_11551966}}
-==About this Structure==
-[[1k0n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K0N OCA].
-==Reference==
-<ref group="xtra">PMID:011551966</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Bauskin, A R.]]
+[[Category: Large Structures]]
-[[Category: Breit, S N.]]
+[[Category: Bauskin AR]]
-[[Category: Campbell, T J.]]
+[[Category: Breit SN]]
-[[Category: Curmi, P M.G.]]
+[[Category: Campbell TJ]]
-[[Category: DeMaere, M Z.]]
+[[Category: Curmi PMG]]
-[[Category: Fairlie, W D.]]
+[[Category: DeMaere MZ]]
-[[Category: Harrop, S J.]]
+[[Category: Fairlie WD]]
-[[Category: Jankova, L.]]
+[[Category: Harrop SJ]]
-[[Category: Mazzanti, M.]]
+[[Category: Jankova L]]
-[[Category: Pankhurst, S.]]
+[[Category: Mazzanti M]]
-[[Category: Qiu, M R.]]
+[[Category: Pankhurst S]]
-[[Category: Reztsova, T.]]
+[[Category: Qiu MR]]
-[[Category: Tonini, R.]]
+[[Category: Reztsova T]]
-[[Category: Valenzuela, S M.]]
+[[Category: Tonini R]]
-[[Category: Warton, K.]]
+[[Category: Valenzuela SM]]
-[[Category: Wu, W M.]]
+[[Category: Warton K]]
-[[Category: Chloride ion channel]]
+[[Category: Wu WM]]
-[[Category: Clic1]]
-[[Category: Glutathione]]
-[[Category: Glutathione-s-tranferase superfamily]]
-[[Category: Metal transport]]
-[[Category: Ncc27]]