3uvm: Difference between revisions

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-[[Image:3uvm.jpg|left|200px]]
-<!--
+==Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4==
-The line below this paragraph, containing "STRUCTURE_3uvm", creates the "Structure Box" on the page.
+<StructureSection load='3uvm' size='340' side='right'caption='[[3uvm]], [[Resolution|resolution]] 1.57&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3uvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UVM FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uvm OCA], [https://pdbe.org/3uvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uvm RCSB], [https://www.ebi.ac.uk/pdbsum/3uvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uvm ProSAT]</span></td></tr>
-{{STRUCTURE_3uvm|  PDB=3uvm  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
-===Crystal structure of WDR5 in complex with the WDR5-interacting motif of MLL4===
+==See Also==
+*[[WD-repeat protein 3D structures|WD-repeat protein 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-[[3uvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UVM OCA].
+__TOC__
-[[Category: Histone-lysine N-methyltransferase]]
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Brunzelle, J S.]]
+[[Category: Large Structures]]
-[[Category: Couture, J F.]]
+[[Category: Brunzelle JS]]
-[[Category: Lee, H.]]
+[[Category: Couture J-F]]
-[[Category: Zhang, P.]]
+[[Category: Lee H]]
-[[Category: Beta-propeller]]
+[[Category: Zhang P]]
-[[Category: Chromatin biology]]
-[[Category: Histone h3]]
-[[Category: Nucleus]]
-[[Category: Scaffolding]]
-[[Category: Transcription]]
-[[Category: Trithorax]]