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[[Image:2c9h.gif|left|200px]]<br /><applet load="2c9h" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2c9h, resolution 1.80&Aring;" />
'''STRUCTURE OF MITOCHONDRIAL BETA-KETOACYL SYNTHASE'''<br />


==About this Structure==
==Structure of mitochondrial beta-ketoacyl synthase==
2C9H is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NI:'>NI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Beta-ketoacyl-acyl-carrier-protein_synthase_I Beta-ketoacyl-acyl-carrier-protein synthase I], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.41 2.3.1.41] Known structural/functional Site: <scene name='pdbsite=AC1:Ni+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9H OCA].  
<StructureSection load='2c9h' size='340' side='right'caption='[[2c9h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
[[Category: Beta-ketoacyl-acyl-carrier-protein synthase I]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2c9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C9H FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c9h OCA], [https://pdbe.org/2c9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c9h RCSB], [https://www.ebi.ac.uk/pdbsum/2c9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c9h ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/OXSM_HUMAN OXSM_HUMAN] May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.<ref>PMID:15668256</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/2c9h_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c9h ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith C]]
[[Category: Bunkoczi, G.]]
[[Category: Bunkoczi G]]
[[Category: Delft, F.Von.]]
[[Category: Edwards A]]
[[Category: Edwards, A.]]
[[Category: Gileadi O]]
[[Category: Gileadi, O.]]
[[Category: Oppermann U]]
[[Category: Oppermann, U.]]
[[Category: Smee C]]
[[Category: Smee, C.]]
[[Category: Sundstrom M]]
[[Category: Sundstrom, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Wu X]]
[[Category: Wu, X.]]
[[Category: Von Delft F]]
[[Category: NI]]
[[Category: fatty acid synthesis]]
[[Category: ketoacyl synthase]]
[[Category: mitochondria]]
[[Category: transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 10:33:07 2008''

Latest revision as of 17:10, 13 December 2023

Structure of mitochondrial beta-ketoacyl synthaseStructure of mitochondrial beta-ketoacyl synthase

Structural highlights

2c9h is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OXSM_HUMAN May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Zhang L, Joshi AK, Hofmann J, Schweizer E, Smith S. Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. J Biol Chem. 2005 Apr 1;280(13):12422-9. Epub 2005 Jan 24. PMID:15668256 doi:M413686200

2c9h, resolution 1.80Å

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