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Ketan Mathavan/Sandbox 1: Difference between revisions

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<Structure load='3spa' size='400' frame='true' align='right' caption='Human mitochondrial RNA polymerase (3SPA)' scene='Labelled' />
 
[[Image:intactModelLargeText.jpg|frame|Bacterial chemotaxis receptor]]
[[Image:intactModelLargeText.jpg|frame|Bacterial chemotaxis receptor]]
Many bacteria can "smell" their surroundings and "choose" where to go. They detect molecules such as amino acids or sugars using receptors that bind these molecules and transmit a signal into the cell. This signal controls several proteins which ultimately control the motors that rotate the flagella to cause the cell to either continue swimming or to tumble. When an attractant molecule binds, it signals: "Things look good, keep swimming!" The opposite signal occurs when bacteria sense decreasing concentrations of attractant molecules: "Time to tumble and try a new swimming direction."


A bacterial chemotaxis receptor is an unusually long alpha-helical structure. The attractant molecule (the ligand) binds near the top of this picture and sends a signal across the membrane into the cell to control proteins that bind near the bottom. This is a model of the structure of the receptor based on experimental structures of pieces of related proteins.
A bacterial chemotaxis receptor is an unusually long alpha-helical structure. The attractant molecule (the ligand) binds near the top of this picture and sends a signal across the membrane into the cell to control proteins that bind near the bottom. This is a model of the structure of the receptor based on experimental structures of pieces of related proteins.


{{Clear}}
{{Clear}}
<applet load='1wat' size='[450,338]' frame='true' align='right'
<applet load='3spa' size='[450,338]' frame='true' align='right'
caption='Aspartate receptor ligand binding domain (1wat)' scene='User:Lynmarie_K_Thompson/Sandbox_1/Loadedfrompdb/4'/>
caption='Human mitochondrial RNA polymerase (3spa)' scene='User:Ketan_Mathavan/Sandbox_1/Loadedfrompdb/4'/>


=== Ligand-binding domain ===
=== Ligand-binding domain ===

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Ketan Mathavan
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