3uv2: Difference between revisions

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-'''Unreleased structure'''
-The entry 3uv2 is ON HOLD
+==Crystal structure of the bromodomain of human nucleosome-remodeling factor subunit BPTF==
+<StructureSection load='3uv2' size='340' side='right'caption='[[3uv2]], [[Resolution|resolution]] 1.58&Aring;' scene=''>
-Authors: Filippakopoulos, P., Picaud, S., Keates, T., Ugochukwu, E., von Delf, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3uv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV2 FirstGlance]. <br>
-Description: Crystal structure of the bromodomain of human nucleosome-remodeling factor subunit BPTF
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PE:2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL'>7PE</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv2 OCA], [https://pdbe.org/3uv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv2 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv2 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Arrowsmith CH]]
+[[Category: Bountra C]]
+[[Category: Edwards AM]]
+[[Category: Filippakopoulos P]]
+[[Category: Keates T]]
+[[Category: Knapp S]]
+[[Category: Picaud S]]
+[[Category: Ugochukwu E]]
+[[Category: Weigelt J]]
+[[Category: Von Delft F]]