3uv2: Difference between revisions
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New page: '''Unreleased structure''' The entry 3uv2 is ON HOLD Authors: Filippakopoulos, P., Picaud, S., Keates, T., Ugochukwu, E., von Delf, F., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bou... |
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==Crystal structure of the bromodomain of human nucleosome-remodeling factor subunit BPTF== | |||
<StructureSection load='3uv2' size='340' side='right'caption='[[3uv2]], [[Resolution|resolution]] 1.58Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3uv2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UV2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7PE:2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL'>7PE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3uv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uv2 OCA], [https://pdbe.org/3uv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3uv2 RCSB], [https://www.ebi.ac.uk/pdbsum/3uv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3uv2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Edwards AM]] | |||
[[Category: Filippakopoulos P]] | |||
[[Category: Keates T]] | |||
[[Category: Knapp S]] | |||
[[Category: Picaud S]] | |||
[[Category: Ugochukwu E]] | |||
[[Category: Weigelt J]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 17:08, 14 March 2024
Crystal structure of the bromodomain of human nucleosome-remodeling factor subunit BPTFCrystal structure of the bromodomain of human nucleosome-remodeling factor subunit BPTF
Structural highlights
FunctionBPTF_HUMAN Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. |
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