3un9: Difference between revisions

Latest revision as of 13:25, 1 March 2024

Crystal structure of an immune receptorCrystal structure of an immune receptor

Structural highlights

3un9 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.65Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NLRX1_HUMAN Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).^[1] ^[2]

References

↑ Tattoli I, Carneiro LA, Jehanno M, Magalhaes JG, Shu Y, Philpott DJ, Arnoult D, Girardin SE. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Rep. 2008 Mar;9(3):293-300. doi: 10.1038/sj.embor.7401161. Epub 2008 Jan 25. PMID:18219313 doi:http://dx.doi.org/10.1038/sj.embor.7401161
↑ Moore CB, Bergstralh DT, Duncan JA, Lei Y, Morrison TE, Zimmermann AG, Accavitti-Loper MA, Madden VJ, Sun L, Ye Z, Lich JD, Heise MT, Chen Z, Ting JP. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature. 2008 Jan 31;451(7178):573-7. Epub 2008 Jan 16. PMID:18200010 doi:http://dx.doi.org/nature06501

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OCA

[1] Tattoli I, Carneiro LA, Jehanno M, Magalhaes JG, Shu Y, Philpott DJ, Arnoult D, Girardin SE. NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Rep. 2008 Mar;9(3):293-300. doi: 10.1038/sj.embor.7401161. Epub 2008 Jan 25. PMID:18219313 doi:http://dx.doi.org/10.1038/sj.embor.7401161

[2] Moore CB, Bergstralh DT, Duncan JA, Lei Y, Morrison TE, Zimmermann AG, Accavitti-Loper MA, Madden VJ, Sun L, Ye Z, Lich JD, Heise MT, Chen Z, Ting JP. NLRX1 is a regulator of mitochondrial antiviral immunity. Nature. 2008 Jan 31;451(7178):573-7. Epub 2008 Jan 16. PMID:18200010 doi:http://dx.doi.org/nature06501

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 3un9 is ON HOLD
+==Crystal structure of an immune receptor==
+<StructureSection load='3un9' size='340' side='right'caption='[[3un9]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-Authors: Hong, M., Yoon, S.I., Wilson, I.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3un9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UN9 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3un9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3un9 OCA], [https://pdbe.org/3un9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3un9 RCSB], [https://www.ebi.ac.uk/pdbsum/3un9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3un9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NLRX1_HUMAN NLRX1_HUMAN] Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).<ref>PMID:18219313</ref> <ref>PMID:18200010</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Hong M]]
+[[Category: Wilson IA]]
+[[Category: Yoon SI]]

3un9: Difference between revisions

Latest revision as of 13:25, 1 March 2024

Crystal structure of an immune receptorCrystal structure of an immune receptor

Structural highlights

Function

References

Contents

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3un9: Difference between revisions

Latest revision as of 13:25, 1 March 2024

Crystal structure of an immune receptorCrystal structure of an immune receptor

Structural highlights

Function

References

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