2llf: Difference between revisions
New page: '''Unreleased structure''' The entry 2llf is ON HOLD Authors: Pfaff, D.A., Brockerman, J., Fedechkin, S., Burns, L., Zhang, F., McKnight, C., Smirnov, S.L. Description: Sixth Gelsolin-... |
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==Sixth Gelsolin-like domain of villin in 5 mM CaCl2== | |||
<StructureSection load='2llf' size='340' side='right'caption='[[2llf]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2llf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LLF FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2llf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2llf OCA], [https://pdbe.org/2llf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2llf RCSB], [https://www.ebi.ac.uk/pdbsum/2llf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2llf ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/VILI_CHICK VILI_CHICK] Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair (By similarity). Its actin-bundling activity is inhibited by tropomyosin.<ref>PMID:3793760</ref> <ref>PMID:1618806</ref> | |||
==See Also== | |||
*[[Villin|Villin]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Gallus gallus]] | |||
[[Category: Large Structures]] | |||
[[Category: Brockerman J]] | |||
[[Category: Burns L]] | |||
[[Category: Fedechkin S]] | |||
[[Category: Mcknight C]] | |||
[[Category: Pfaff DA]] | |||
[[Category: Smirnov SL]] | |||
[[Category: Zhang F]] | |||