1jn3: Difference between revisions

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-[[Image:1jn3.png|left|200px]]
-<!--
+==FIDELITY PROPERTIES AND STRUCTURE OF M282L MUTATOR MUTANT OF DNA POLYMERASE: SUBTLE STRUCTURAL CHANGES INFLUENCE THE MECHANISM OF NUCLEOTIDE DISCRIMINATION==
-The line below this paragraph, containing "STRUCTURE_1jn3", creates the "Structure Box" on the page.
+<StructureSection load='1jn3' size='340' side='right'caption='[[1jn3]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1jn3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JN3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JN3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jn3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jn3 OCA], [https://pdbe.org/1jn3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jn3 RCSB], [https://www.ebi.ac.uk/pdbsum/1jn3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jn3 ProSAT]</span></td></tr>
-{{STRUCTURE_1jn3|  PDB=1jn3  |  SCENE=  }}
+</table>
+== Function ==
-===FIDELITY PROPERTIES AND STRUCTURE OF M282L MUTATOR MUTANT OF DNA POLYMERASE: SUBTLE STRUCTURAL CHANGES INFLUENCE THE MECHANISM OF NUCLEOTIDE DISCRIMINATION===
+[https://www.uniprot.org/uniprot/DPOLB_RAT DPOLB_RAT] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-<!--
+Check<jmol>
-The line below this paragraph, {{ABSTRACT_PUBMED_11560485}}, adds the Publication Abstract to the page
+  <jmolCheckbox>
-(as it appears on PubMed at http://www.pubmed.gov), where 11560485 is the PubMed ID number.
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jn/1jn3_consurf.spt"</scriptWhenChecked>
--->
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-{{ABSTRACT_PUBMED_11560485}}
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==About this Structure==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jn3 ConSurf].
-[[1jn3]] is a 1 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JN3 OCA].
+<div style="clear:both"></div>
 ==See Also==
-*[[DNA polymerase]]
+*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-<ref group="xtra">PMID:011560485</ref><references group="xtra"/>
+[[Category: Large Structures]]
-[[Category: DNA-directed DNA polymerase]]
 [[Category: Rattus norvegicus]]
-[[Category: Conn, D A.]]
+[[Category: Conn DA]]
-[[Category: Jaeger, J.]]
+[[Category: Jaeger J]]
-[[Category: Sweasy, J B.]]
+[[Category: Sweasy JB]]
-[[Category: Mutant]]
-[[Category: Nucleotide discrimination]]
-[[Category: Transferase]]