Pertussis Toxin-ATP Complex: Difference between revisions
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Early treatment of pertussis is the only effective way to treat the bacterial infection. If treatment for pertussis is started early in the course of illness during the 1 to 2 weeks before severe coughing occurs, the symptoms may be lessened.<ref>Centers for Disease Control and Prevention. http://www.cdc.gov/pertussis/clinical/treatment.html</ref>The preferred antibiotics are that inhibit protein synthesis such as: [http://en.wikipedia.org/wiki/Erythromycin Erythromycin], [http://en.wikipedia.org/wiki/Clarithromycin Clarithromycin], and [http://en.wikipedia.org/wiki/Azithromycin Azithromycin].<ref name=Altunaiji>PMID: 17636756</ref> If the diagnosed to late, antibiotics will not alter the course of the illness since the bacteria is already producing the PT toxin. | Early treatment of pertussis is the only effective way to treat the bacterial infection. If treatment for pertussis is started early in the course of illness during the 1 to 2 weeks before severe coughing occurs, the symptoms may be lessened.<ref>Centers for Disease Control and Prevention. http://www.cdc.gov/pertussis/clinical/treatment.html</ref>The preferred antibiotics are that inhibit protein synthesis such as: [http://en.wikipedia.org/wiki/Erythromycin Erythromycin], [http://en.wikipedia.org/wiki/Clarithromycin Clarithromycin], and [http://en.wikipedia.org/wiki/Azithromycin Azithromycin].<ref name=Altunaiji>PMID: 17636756</ref> If the diagnosed to late, antibiotics will not alter the course of the illness since the bacteria is already producing the PT toxin. | ||
The primary method of prevention for pertussis is [http://en.wikipedia.org/wiki/Vaccination vaccination]. The [http://en.wikipedia.org/wiki/DPT_vaccine DTaP vaccine] | The primary method of prevention for pertussis is [http://en.wikipedia.org/wiki/Vaccination vaccination]. The [http://en.wikipedia.org/wiki/DPT_vaccine DTaP vaccine] is used and this vaccine is composed of diphtheria, tetanus, and pertussis. The pertussis component is acellular; this acellular component are selected antigens (inactivated pertussis toxin (toxoid) and filamentous hemagglutinin) of pertussis that induces [http://en.wikipedia.org/wiki/Adaptive_immune_system adaptive immunity].<ref>Kenneth Todar, PhD. (2008). http://www.textbookofbacteriology.net/pertussis.html</ref> | ||
==Conclusion== | ==Conclusion== | ||
The findings of PT activation was significant since it illustrated a better understanding for the pathogenesis of the toxin. The key features of this proposal is that ATP binding signals the arrival of the PT in the endoplasmic reticulum by acting as a molecular sensor.<ref name=Hazes>PMID: 8637000</ref> This detection of the PT in the ER at the same time triggers dissociation of the holotoxin prior to membrane translocation.<ref name=Hazes>PMID: 8637000</ref> Therefore, the dissociation is due to ATP binding destabilization, reduction by protein disulphide isomerase, and proteolytic cleavage.<ref name=Hazes>PMID: 8637000</ref> | |||
</StructureSection> | </StructureSection> | ||
==3D structures of Pertussis toxin== | |||
[[Pertussis toxin]] | |||
==References== | ==References== | ||
<references/> | <references/> | ||