3az3: Difference between revisions

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-[[Image:3az3.jpg|left|200px]]
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+==Crystal Structure Analysis of Vitamin D receptor==
-The line below this paragraph, containing "STRUCTURE_3az3", creates the "Structure Box" on the page.
+<StructureSection load='3az3' size='340' side='right'caption='[[3az3]], [[Resolution|resolution]] 1.36&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3az3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AZ3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.36&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DS6:(4S)-4-HYDROXY-5-[4-(3-{4-[(3S)-3-HYDROXY-4,4-DIMETHYLPENTYL]-3-METHYLPHENYL}PENTAN-3-YL)-2-METHYLPHENOXY]PENTANOIC+ACID'>DS6</scene></td></tr>
-{{STRUCTURE_3az3|  PDB=3az3  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3az3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3az3 OCA], [https://pdbe.org/3az3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3az3 RCSB], [https://www.ebi.ac.uk/pdbsum/3az3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3az3 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN] Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:[https://omim.org/entry/277440 277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.<ref>PMID:2849209</ref> <ref>PMID:8381803</ref> <ref>PMID:1652893</ref> <ref>PMID:2177843</ref> <ref>PMID:8106618</ref> <ref>PMID:8392085</ref> <ref>PMID:7828346</ref> <ref>PMID:8675579</ref> <ref>PMID:8961271</ref> <ref>PMID:9005998</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/VDR_HUMAN VDR_HUMAN] Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.<ref>PMID:16252006</ref> <ref>PMID:10678179</ref> <ref>PMID:15728261</ref> <ref>PMID:16913708</ref>
-===Crystal Structure Analysis of Vitamin D receptor===
+==See Also==
+*[[Sandbox vdr|Sandbox vdr]]
+*[[Vitamin D receptor 3D structures|Vitamin D receptor 3D structures]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_21795053}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 21795053 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_21795053}}
-==About this Structure==
-[[3az3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AZ3 OCA].
-==Reference==
-<ref group="xtra">PMID:021795053</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Iijima, S.]]
+[[Category: Large Structures]]
-[[Category: Itoh, S.]]
+[[Category: Iijima S]]
-[[Category: Hormone receptor]]
+[[Category: Itoh S]]
-[[Category: Vitamin d receptor]]