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==Crystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosis== | |||
<StructureSection load='3sgi' size='340' side='right'caption='[[3sgi]], [[Resolution|resolution]] 3.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3sgi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SGI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sgi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sgi OCA], [https://pdbe.org/3sgi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sgi RCSB], [https://www.ebi.ac.uk/pdbsum/3sgi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sgi ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DNLJ_MYCTU DNLJ_MYCTU] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.[HAMAP-Rule:MF_01588] | |||
==See Also== | |||
*[[DNA ligase 3D structures|DNA ligase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Kukshal V]] | |||
[[Category: Ravishankar R]] | |||
Latest revision as of 20:25, 1 November 2023
Crystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosisCrystal structure of DNA ligase A BRCT domain deleted mutant of Mycobacterium tuberculosis
Structural highlights
FunctionDNLJ_MYCTU DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.[HAMAP-Rule:MF_01588] See Also |
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