3u1q: Difference between revisions

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'''Unreleased structure'''


The entry 3u1q is ON HOLD  until sometime in the future
==Crystal Structure of M. tuberculosis LD-transpeptidase type 2 with 2-Mercaptoethanol==
 
<StructureSection load='3u1q' size='340' side='right'caption='[[3u1q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
Authors: Erdemli, S., Bianchet, M. A., Gupta R., Lamichhane G., Amzel L.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3u1q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U1Q FirstGlance]. <br>
Description: Crystal Structure of M. tuberculosis LD-transpeptidase type 2 with 2-Mercaptoethanol
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u1q OCA], [https://pdbe.org/3u1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u1q RCSB], [https://www.ebi.ac.uk/pdbsum/3u1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u1q ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LDT2_MYCTO LDT2_MYCTO] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is essential for virulence in a mouse model of acute infection.<ref>PMID:20305661</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Amzel LM]]
[[Category: Bianchet MA]]
[[Category: Erdemli S]]
[[Category: Gupta R]]
[[Category: Lamichhane G]]

Latest revision as of 13:16, 1 March 2024

Crystal Structure of M. tuberculosis LD-transpeptidase type 2 with 2-MercaptoethanolCrystal Structure of M. tuberculosis LD-transpeptidase type 2 with 2-Mercaptoethanol

Structural highlights

3u1q is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LDT2_MYCTO Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is essential for virulence in a mouse model of acute infection.[1]

References

  1. ↑ Gupta R, Lavollay M, Mainardi JL, Arthur M, Bishai WR, Lamichhane G. The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin. Nat Med. 2010 Apr;16(4):466-9. doi: 10.1038/nm.2120. Epub 2010 Mar 21. PMID:20305661 doi:http://dx.doi.org/10.1038/nm.2120

3u1q, resolution 2.40Å

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