3srr: Difference between revisions

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-[[Image:3srr.png|left|200px]]
-<!--
+==S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines==
-The line below this paragraph, containing "STRUCTURE_3srr", creates the "Structure Box" on the page.
+<StructureSection load='3srr' size='340' side='right'caption='[[3srr]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3srr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SRR FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=Q20:3-(2,4-DIAMINO-6-METHYLQUINAZOLIN-7-YL)-4-ETHOXYBENZALDEHYDE'>Q20</scene></td></tr>
-{{STRUCTURE_3srr|  PDB=3srr  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3srr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3srr OCA], [https://pdbe.org/3srr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3srr RCSB], [https://www.ebi.ac.uk/pdbsum/3srr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3srr ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
-===S. aureus Dihydrofolate Reductase complexed with novel 7-aryl-2,4-diaminoquinazolines===
+==See Also==
+*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_21831637}}, adds the Publication Abstract to the page
+[[Category: Large Structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21831637 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_21831637}}
-==About this Structure==
-[[3srr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SRR OCA].
-==Reference==
-<ref group="xtra">PMID:021831637</ref><references group="xtra"/>
-[[Category: Dihydrofolate reductase]]
 [[Category: Staphylococcus aureus]]
-[[Category: Hilgers, M.]]
+[[Category: Hilgers M]]
-[[Category: Dhfr]]
-[[Category: Dihydrofolate reductase]]
-[[Category: Drug design]]
-[[Category: Enzyme inhibitor]]
-[[Category: Folate]]
-[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]