3ruu: Difference between revisions

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-[[Image:3ruu.png|left|200px]]
-<!--
+==FXR with SRC1 and GSK237==
-The line below this paragraph, containing "STRUCTURE_3ruu", creates the "Structure Box" on the page.
+<StructureSection load='3ruu' size='340' side='right'caption='[[3ruu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ruu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RUU FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=37G:6-(4-{[3-(2,6-DICHLOROPHENYL)-5-(PROPAN-2-YL)-1,2-OXAZOL-4-YL]METHOXY}PHENYL)-1H-INDOLE-3-CARBOXYLIC+ACID'>37G</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3ruu|  PDB=3ruu  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ruu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ruu OCA], [https://pdbe.org/3ruu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ruu RCSB], [https://www.ebi.ac.uk/pdbsum/3ruu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ruu ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
-===FXR with SRC1 and GSK237===
+==See Also==
+*[[Bile acid receptor|Bile acid receptor]]
+*[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]]
-<!--
+== References ==
-The line below this paragraph, {{ABSTRACT_PUBMED_21890356}}, adds the Publication Abstract to the page
+<references/>
-(as it appears on PubMed at http://www.pubmed.gov), where 21890356 is the PubMed ID number.
+__TOC__
--->
+</StructureSection>
-{{ABSTRACT_PUBMED_21890356}}
-==About this Structure==
-[[3ruu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RUU OCA].
-==Reference==
-<ref group="xtra">PMID:021890356</ref><references group="xtra"/>
-[[Category: Histone acetyltransferase]]
 [[Category: Homo sapiens]]
-[[Category: Madauss, K P.]]
+[[Category: Large Structures]]
-[[Category: Williams, S P.]]
+[[Category: Madauss KP]]
-[[Category: Alpha-helical sandwich]]
+[[Category: Williams SP]]
-[[Category: Bile acid]]
-[[Category: Farnesoid]]
-[[Category: Nuclear receptor]]
-[[Category: Rxr]]
-[[Category: Transcription co-factor]]
-[[Category: Transcription factor]]
-[[Category: Transcription regulator]]