3sb7: Difference between revisions

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[[Image:3sb7.jpg|left|200px]]


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==Cu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization==
The line below this paragraph, containing "STRUCTURE_3sb7", creates the "Structure Box" on the page.
<StructureSection load='3sb7' size='340' side='right'caption='[[3sb7]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3sb7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SB7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_3sb7|  PDB=3sb7  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sb7 OCA], [https://pdbe.org/3sb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sb7 RCSB], [https://www.ebi.ac.uk/pdbsum/3sb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sb7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref>  


===Cu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization===
==See Also==
 
*[[Lysozyme 3D structures|Lysozyme 3D structures]]
 
== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 21898649 is the PubMed ID number.
</StructureSection>
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[[Category: Escherichia virus T4]]
{{ABSTRACT_PUBMED_21898649}}
[[Category: Large Structures]]
 
[[Category: Cascio D]]
==About this Structure==
[[Category: Laganowsky A]]
[[3sb7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SB7 OCA].
[[Category: Sawaya MR]]
 
[[Category: Soriaga AB]]
==Reference==
[[Category: Yeates TO]]
<ref group="xtra">PMID:021898649</ref><references group="xtra"/>
[[Category: Zhao M]]
[[Category: Enterobacteria phage t4]]
[[Category: Lysozyme]]
[[Category: Cascio, D.]]
[[Category: Laganowsky, A.]]
[[Category: Sawaya, M R.]]
[[Category: Soriaga, A B.]]
[[Category: Yeates, T O.]]
[[Category: Zhao, M.]]
[[Category: Hydrolase]]
[[Category: Metal-mediated synthetic symmetrization]]
[[Category: Synthetic symmetrization]]

Latest revision as of 12:49, 1 March 2024

Cu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic SymmetrizationCu-mediated Trimer of T4 Lysozyme D61H/K65H/R76H/R80H by Synthetic Symmetrization

Structural highlights

3sb7 is a 2 chain structure with sequence from Escherichia virus T4. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.7Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ENLYS_BPT4 Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.[1]

See Also

References

  1. ↑ Moussa SH, Kuznetsov V, Tran TA, Sacchettini JC, Young R. Protein determinants of phage T4 lysis inhibition. Protein Sci. 2012 Apr;21(4):571-82. doi: 10.1002/pro.2042. Epub 2012 Mar 2. PMID:22389108 doi:http://dx.doi.org/10.1002/pro.2042

3sb7, resolution 2.70Å

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