3tkj: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 3tkj is ON HOLD
+==Crystal Structure of Human Asparaginase-like Protein 1 Thr168Ala==
+<StructureSection load='3tkj' size='340' side='right'caption='[[3tkj]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3tkj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TKJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TKJ FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TAM:TRIS(HYDROXYETHYL)AMINOMETHANE'>TAM</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tkj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tkj OCA], [https://pdbe.org/3tkj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tkj RCSB], [https://www.ebi.ac.uk/pdbsum/3tkj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tkj ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ASGL1_HUMAN ASGL1_HUMAN] Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.<ref>PMID:19839645</ref>
-Authors: Li, W.Z., Liu, J., Zhang, Y.
+==See Also==
+*[[Asparaginase 3D structures|Asparaginase 3D structures]]
-Description: Crystal Structure of Human Asparaginase-like Protein 1 Bound to Product L-Aspartic Acid
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li WZ]]
+[[Category: Liu J]]
+[[Category: Yogesha SD]]
+[[Category: Zhang Y]]