3rl0: Difference between revisions

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-[[Image:3rl0.png|left|200px]]
-<!--
+==Truncated SNARE complex with complexin (P1)==
-The line below this paragraph, containing "STRUCTURE_3rl0", creates the "Structure Box" on the page.
+<StructureSection load='3rl0' size='340' side='right'caption='[[3rl0]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3rl0]] is a 40 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RL0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-{{STRUCTURE_3rl0|  PDB=3rl0  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rl0 OCA], [https://pdbe.org/3rl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rl0 RCSB], [https://www.ebi.ac.uk/pdbsum/3rl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rl0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SNP25_HUMAN SNP25_HUMAN] t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Complexin prevents SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. To understand the mechanism for this inhibition, we determined the structure of complexin bound to a mimetic of a prefusion SNAREpin lacking the portion of the v-SNARE that zippers last to trigger fusion. The 'central helix' of complexin is anchored to one SNARE complex, while its 'accessory helix' extends away at ~45 degrees and bridges to a second complex, occupying the vacant v-SNARE binding site to inhibit fusion. We expected the accessory helix to compete with the v-SNARE for t-SNARE binding but found instead that the interaction occurs intermolecularly. Thus, complexin organizes the SNAREs into a zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion.
-===Truncated SNARE complex with complexin (P1)===
+Complexin cross-links prefusion SNAREs into a zigzag array.,Kummel D, Krishnakumar SS, Radoff DT, Li F, Giraudo CG, Pincet F, Rothman JE, Reinisch KM Nat Struct Mol Biol. 2011 Jul 24;18(8):927-33. doi: 10.1038/nsmb.2101. PMID:21785414<ref>PMID:21785414</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3rl0" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21785414}}, adds the Publication Abstract to the page
+*[[Complexin|Complexin]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21785414 is the PubMed ID number.
+*[[Synaptosomal-associated protein|Synaptosomal-associated protein]]
--->
+*[[Syntaxin 3D structures|Syntaxin 3D structures]]
-{{ABSTRACT_PUBMED_21785414}}
+*[[Vesicle-associated membrane protein 3D structures|Vesicle-associated membrane protein 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-[[3rl0]] is a 40 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RL0 OCA].
+__TOC__
+</StructureSection>
-==Reference==
-<ref group="xtra">PMID:021785414</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
+[[Category: Large Structures]]
 [[Category: Rattus norvegicus]]
-[[Category: Kuemmel, D.]]
+[[Category: Kuemmel D]]
-[[Category: Reinisch, K M.]]
+[[Category: Reinisch KM]]
-[[Category: Membrane fusion]]
-[[Category: Membrane protein-exocytosis complex]]
-[[Category: Snare protein]]