407d: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
New page: left|200px<br /><applet load="407d" size="350" color="white" frame="true" align="right" spinBox="true" caption="407d, resolution 2.200Å" /> '''STRUCTURAL BASIS FO...
 
No edit summary
 
(13 intermediate revisions by the same user not shown)
Line 1: Line 1:
[[Image:407d.gif|left|200px]]<br /><applet load="407d" size="350" color="white" frame="true" align="right" spinBox="true"
caption="407d, resolution 2.200&Aring;" />
'''STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA'''<br />


==Overview==
==STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA==
Polyamide dimers containing three types of aromatic rings-pyrrole, imidazole, and hydroxypyrrole-afford a small-molecule recognition code, that discriminates among all four Watson-Crick base pairs in the minor, groove. The crystal structure of a specific polyamide dimer-DNA complex, establishes the structural basis for distinguishing T.A from A.T base, pairs. Specificity for the T.A base pair is achieved by means of distinct, hydrogen bonds between pairs of substituted pyrroles on the ligand and the, O2 of thymine and N3 of adenine. In addition, shape-selective recognition, of an asymmetric cleft between the thymine-O2 and the adenine-C2 was, observed. Although hitherto similarities among the base pairs in the minor, groove have been emphasized, the structure illustrates differences that, allow specific minor groove recognition.
<StructureSection load='407d' size='340' side='right'caption='[[407d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[407d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=407D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=407D FirstGlance]. <br>
407D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=HP1:'>HP1</scene> and <scene name='pdbligand=TRS:'>TRS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=407D OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HP1:IMIDAZOLE-PYRROLE-HYDROXYPYRROLE+POLYAMIDE'>HP1</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=407d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=407d OCA], [https://pdbe.org/407d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=407d RCSB], [https://www.ebi.ac.uk/pdbsum/407d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=407d ProSAT]</span></td></tr>
A structural basis for recognition of A.T and T.A base pairs in the minor groove of B-DNA., Kielkopf CL, White S, Szewczyk JW, Turner JM, Baird EE, Dervan PB, Rees DC, Science. 1998 Oct 2;282(5386):111-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9756473 9756473]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Rees]]
</StructureSection>
[[Category: HP1]]
[[Category: Large Structures]]
[[Category: TRS]]
[[Category: Synthetic construct]]
[[Category: drugs in the dna minor groove]]
[[Category: Rees DC]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:42:18 2008''

Latest revision as of 13:36, 1 March 2024

STRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNASTRUCTURAL BASIS FOR RECOGNITION OF A-T AND T-A BASE PAIRS IN THE MINOR GROOVE OF B-DNA

Structural highlights

407d is a 2 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

407d, resolution 2.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=407d&oldid=4072764"