365d: Difference between revisions

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New page: left|200px<br /><applet load="365d" size="350" color="white" frame="true" align="right" spinBox="true" caption="365d, resolution 2.000Å" /> '''STRUCTURAL BASIS FO...
 
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'''STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE'''<br />


==Overview==
==STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE==
Small molecules that target specific DNA sequences offer a potentially, general approach for the regulation of gene expression. Pyrrole-imidazole, polyamides represent the only class of synthetic small molecules that can, bind predetermined DNA sequences with affinities and specificities, comparable to DNA binding proteins. Antiparallel side-by-side pairings of, two aromatic amino acids, imidazole (Im) and pyrrole (Py), distinguish G.C, from C.G, and both from A.T/T.A base pairs. A high resolution X-ray, crystal structure of a four-ring pyrrole-imidazole polyamide specifically, bound as a dimer to a six-base pair predetermined DNA site reveals a, structural framework of hydrogen bonds and interactions with the walls of, the minor groove that underlies the pairing rules for DNA recognition.
<StructureSection load='365d' size='340' side='right'caption='[[365d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[365d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=365D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=365D FirstGlance]. <br>
365D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=IIP:'>IIP</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=365D OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=IIP:IMIDAZOLE-PYRROLE+POLYAMIDE'>IIP</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=365d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=365d OCA], [https://pdbe.org/365d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=365d RCSB], [https://www.ebi.ac.uk/pdbsum/365d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=365d ProSAT]</span></td></tr>
Structural basis for G.C recognition in the DNA minor groove., Kielkopf CL, Baird EE, Dervan PB, Rees DC, Nat Struct Biol. 1998 Feb;5(2):104-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9461074 9461074]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Baird, E.E.]]
</StructureSection>
[[Category: Dervan, P.B.]]
[[Category: Large Structures]]
[[Category: Kielkopf, C.L.]]
[[Category: Baird EE]]
[[Category: Rees, D.C.]]
[[Category: Dervan PB]]
[[Category: IIP]]
[[Category: Kielkopf CL]]
[[Category: b-dna]]
[[Category: Rees DC]]
[[Category: double helix]]
[[Category: modified]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 21:36:46 2008''

Latest revision as of 11:39, 7 February 2024

STRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVESTRUCTURAL BASIS FOR G C RECOGNITION IN THE DNA MINOR GROOVE

Structural highlights

365d is a 2 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

365d, resolution 2.00Å

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