2yh3: Difference between revisions

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-[[Image:2yh3.png|left|200px]]
-<!--
+==The structure of BamB from E. coli==
-The line below this paragraph, containing "STRUCTURE_2yh3", creates the "Structure Box" on the page.
+<StructureSection load='2yh3' size='340' side='right'caption='[[2yh3]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2yh3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YH3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yh3 OCA], [https://pdbe.org/2yh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yh3 RCSB], [https://www.ebi.ac.uk/pdbsum/2yh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yh3 ProSAT]</span></td></tr>
-{{STRUCTURE_2yh3|  PDB=2yh3  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BAMB_ECOLI BAMB_ECOLI] Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Nonessential member of the complex, which may orient the flexible periplasmic domain of BamA for interaction with other Bam components, chaperones and nascent outer membrane proteins.<ref>PMID:20378773</ref> <ref>PMID:21823654</ref> <ref>PMID:21586578</ref> <ref>PMID:21277859</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In Escherichia coli, a multicomponent BAM (beta-barrel assembly machinery) complex is responsible for recognition and assembly of outer membrane beta-barrel proteins. The functionality of BAM in protein biogenesis is mainly orchestrated through the presence of two essential components, BamA and BamD. Here, we present crystal structures of four lipoproteins (BamB-E). Monomeric BamB and BamD proteins display scaffold architectures typically implied in transient protein interactions. BamB is a beta-propeller protein comprising eight WD40 repeats. BamD shows an elongated fold on the basis of five tetratricopeptide repeats, three of which form the scaffold for protein recognition. The rod-shaped BamC protein has evolved through the gene duplication of two conserved domains known to mediate protein interactions in structurally related complexes. By contrast, the dimeric BamE is formed through a domain swap and indicates fold similarity to the beta-lactamase inhibitor protein family, possibly integrating cell wall stability in BAM function. Structural and biochemical data show evidence for the specific recognition of amphipathic sequences through the tetratricopeptide repeat architecture of BamD. Collectively, our data advance the understanding of the BAM complex and highlight the functional importance of BamD in amphipathic outer membrane beta-barrel protein motif recognition and protein delivery.
-===THE STRUCTURE OF BAMB FROM E. COLI===
+Structural basis of outer membrane protein biogenesis in bacteria.,Albrecht R, Zeth K J Biol Chem. 2011 Aug 5;286(31):27792-803. Epub 2011 May 17. PMID:21586578<ref>PMID:21586578</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2yh3" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21586578}}, adds the Publication Abstract to the page
+*[[Bam complex 3D structures|Bam complex 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21586578 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21586578}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Escherichia coli K-12]]
-[[2yh3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YH3 OCA].
+[[Category: Large Structures]]
+[[Category: Albrecht R]]
-==Reference==
+[[Category: Zeth K]]
-<ref group="xtra">PMID:021586578</ref><references group="xtra"/>
-[[Category: Escherichia coli]]
-[[Category: Albrecht, R.]]
-[[Category: Zeth, K.]]
-[[Category: Bam complex]]
-[[Category: Lipid binding protein]]
-[[Category: Propeller fold]]