3s3y: Difference between revisions

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-[[Image:3s3y.png|left|200px]]
-<!--
+==Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0==
-The line below this paragraph, containing "STRUCTURE_3s3y", creates the "Structure Box" on the page.
+<StructureSection load='3s3y' size='340' side='right'caption='[[3s3y]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3s3y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S3Y FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-{{STRUCTURE_3s3y|  PDB=3s3y  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s3y OCA], [https://pdbe.org/3s3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s3y RCSB], [https://www.ebi.ac.uk/pdbsum/3s3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s3y ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CVN_NOSEL CVN_NOSEL] Mannose-binding lectin.<ref>PMID:9210678</ref> <ref>PMID:12678493</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Cyanovirin-N (CV-N) is a small, cyanobacterial lectin that neutralizes many enveloped viruses, including human immunodeficiency virus type I (HIV-1). This antiviral activity is attributed to two homologous carbohydrate binding sites that specifically bind high mannose glycosylation present on envelope glycoproteins such as HIV-1 gp120. We created obligate CV-N oligomers to determine whether increasing the number of binding sites has an effect on viral neutralization. A tandem repeat of two CV-N molecules (CVN(2)) increased HIV-1 neutralization activity by up to 18-fold compared to wild-type CV-N. In addition, the CVN(2) variants showed extensive cross-clade reactivity and were often more potent than broadly neutralizing anti-HIV antibodies. The improvement in activity and broad cross-strain HIV neutralization exhibited by these molecules holds promise for the future therapeutic utility of these and other engineered CV-N variants.
-===Crystal Structure an Tandem Cyanovirin-N Dimer, CVN2L0===
+Designed oligomers of cyanovirin-N show enhanced HIV neutralization.,Keeffe JR, Gnanapragasam PN, Gillespie SK, Yong J, Bjorkman PJ, Mayo SL Proc Natl Acad Sci U S A. 2011 Jul 28. PMID:21799112<ref>PMID:21799112</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_21799112}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3s3y" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 21799112 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21799112}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-[[3s3y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_ellipsosporum Nostoc ellipsosporum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S3Y OCA].
-==Reference==
-<ref group="xtra">PMID:021799112</ref><references group="xtra"/>
 [[Category: Nostoc ellipsosporum]]
-[[Category: Bjorkman, P J.]]
+[[Category: Bjorkman PJ]]
-[[Category: Keeffe, J R.]]
+[[Category: Keeffe JR]]
-[[Category: Mayo, S L.]]
+[[Category: Mayo SL]]
-[[Category: Antiviral protein]]
-[[Category: Cyanovirin-n]]
-[[Category: Engineered dimer]]
-[[Category: Gp120]]
-[[Category: Sugar-binding]]