1alx: Difference between revisions

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-[[Image:1alx.png|left|200px]]
-<!--
+==GRAMICIDIN D FROM BACILLUS BREVIS (METHANOL SOLVATE)==
-The line below this paragraph, containing "STRUCTURE_1alx", creates the "Structure Box" on the page.
+<StructureSection load='1alx' size='340' side='right'caption='[[1alx]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1alx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ALX FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DLE:D-LEUCINE'>DLE</scene>, <scene name='pdbligand=DVA:D-VALINE'>DVA</scene>, <scene name='pdbligand=ETA:ETHANOLAMINE'>ETA</scene>, <scene name='pdbligand=FVA:N-FORMYL-L-VALINE'>FVA</scene>, <scene name='pdbligand=MOH:METHANOL'>MOH</scene>, <scene name='pdbligand=PRD_000152:GRAMICIDIN+D'>PRD_000152</scene></td></tr>
-{{STRUCTURE_1alx|  PDB=1alx  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1alx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1alx OCA], [https://pdbe.org/1alx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1alx RCSB], [https://www.ebi.ac.uk/pdbsum/1alx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1alx ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The linear pentadecapeptide antibiotic gramicidin D is a heterogeneous mixture of six components. Precise refinements of three-dimensional structures of naturally occurring gramicidin D in crystals obtained from methanol, ethanol, and n-propanol demonstrate the unexpected presence of stable left-handed antiparallel double-helical heterodimers that vary with the crystallization solvent. The side chains of Trp residues in the three structures exhibit sequence-specific patterns of conformational preference. Tyr substitution for Trp at position 11 appears to favor beta ribbon formation and stabilization of the antiparallel double helix that acts as a template for gramicidin folding and nucleation of different crystal forms. The fact that a minor component in a heterogeneous mixture influences aggregation and crystal nucleation has potential applications to other systems in which anomalous behavior is exhibited by aggregation of apparently homogeneous materials, such as the enigmatic behavior of prion proteins.
-===GRAMICIDIN D FROM BACILLUS BREVIS (METHANOL SOLVATE)===
+Heterodimer formation and crystal nucleation of gramicidin D.,Burkhart BM, Gassman RM, Langs DA, Pangborn WA, Duax WL Biophys J. 1998 Nov;75(5):2135-46. PMID:9788907<ref>PMID:9788907</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_9788907}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1alx" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 9788907 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_9788907}}
-==About this Structure==
-[[1alx]] is a 2 chain structure of [[Gramicidin]] with sequence from [http://en.wikipedia.org/wiki/Brevibacillus_brevis Brevibacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ALX OCA].
 ==See Also==
-*[[Gramicidin]]
+*[[Gramicidin|Gramicidin]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:009788907</ref><ref group="xtra">PMID:001711230</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Brevibacillus brevis]]
-[[Category: Burkhart, B M.]]
+[[Category: Large Structures]]
-[[Category: Courseille, C.]]
+[[Category: Burkhart BM]]
-[[Category: Duax, W L.]]
+[[Category: Courseille C]]
-[[Category: Hospital, M.]]
+[[Category: Duax WL]]
-[[Category: Langs, D A.]]
+[[Category: Hospital M]]
-[[Category: Pangborn, W A.]]
+[[Category: Langs DA]]
-[[Category: Precigoux, G.]]
+[[Category: Pangborn WA]]
-[[Category: Smith, G D.]]
+[[Category: Precigoux G]]
-[[Category: Abtibiotic]]
+[[Category: Smith GD]]
-[[Category: Antibacterial]]
-[[Category: Antibiotic]]
-[[Category: Antifungal]]
-[[Category: Gramicidin]]
-[[Category: Linear gramicidin]]
-[[Category: Membrane ion channel]]