3qlw: Difference between revisions

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-[[Image:3qlw.jpg|left|200px]]
-<!--
+==Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (UCP120B)==
-The line below this paragraph, containing "STRUCTURE_3qlw", creates the "Structure Box" on the page.
+<StructureSection load='3qlw' size='340' side='right'caption='[[3qlw]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3qlw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QLW FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.504&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=N22:5-[3-(2,5-DIMETHOXYPHENYL)PROP-1-YN-1-YL]-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>N22</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
-{{STRUCTURE_3qlw|  PDB=3qlw  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qlw OCA], [https://pdbe.org/3qlw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qlw RCSB], [https://www.ebi.ac.uk/pdbsum/3qlw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qlw ProSAT]</span></td></tr>
+</table>
-===Candida albicans dihydrofolate reductase complexed with NADPH and 5-[3-(2,5-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylpyrimidine-2,4-diamine (UCP120B)===
+== Function ==
+[https://www.uniprot.org/uniprot/DYR_CANAX DYR_CANAX] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_21726415}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 21726415 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_21726415}}
-==About this Structure==
-[[3qlw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QLW OCA].
-==Reference==
-<ref group="xtra">PMID:021726415</ref><references group="xtra"/>
 [[Category: Candida albicans]]
-[[Category: Anderson, A C.]]
+[[Category: Large Structures]]
-[[Category: Bendel, S D.]]
+[[Category: Anderson AC]]
-[[Category: Paulsen, J L.]]
+[[Category: Bendel SD]]
-[[Category: Antifungal agent]]
+[[Category: Paulsen JL]]
-[[Category: Candida albican]]
-[[Category: Drug design]]
-[[Category: Enzyme inhibitor]]
-[[Category: Fungal protein]]
-[[Category: Model]]
-[[Category: Molecular structure]]
-[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
-[[Category: Structure-activity relationship]]
-[[Category: Tetrahydrofolate dehydrogenase]]