3sm9: Difference between revisions
Jump to navigation
Jump to search
m Protected "3sm9" [edit=sysop:move=sysop] |
No edit summary |
||
| (7 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist== | |||
<StructureSection load='3sm9' size='340' side='right'caption='[[3sm9]], [[Resolution|resolution]] 2.26Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3sm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SM9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=Z99:2-[(1S,2S)-2-CARBOXYCYCLOPROPYL]-3-(9H-XANTHEN-9-YL)-D-ALANINE'>Z99</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sm9 OCA], [https://pdbe.org/3sm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sm9 RCSB], [https://www.ebi.ac.uk/pdbsum/3sm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sm9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GRM3_HUMAN GRM3_HUMAN] G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.<ref>PMID:8840013</ref> | |||
==See Also== | |||
*[[Metabotropic glutamate receptor 3D structures|Metabotropic glutamate receptor 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Cossar D]] | |||
[[Category: Crombet L]] | |||
[[Category: Dobrovetsky E]] | |||
[[Category: Dong A]] | |||
[[Category: Edwards AM]] | |||
[[Category: Khutoreskaya G]] | |||
[[Category: Seitova A]] | |||
[[Category: Weigelt J]] | |||
[[Category: Wernimont AK]] | |||
Latest revision as of 16:01, 14 March 2024
Crystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonistCrystal Structure of Metabotropic glutamate receptor 3 precursor in presence of LY341495 antagonist
Structural highlights
FunctionGRM3_HUMAN G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.[1] See AlsoReferences |
| ||||||||||||||||||