2lc3: Difference between revisions

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[[Image:2lc3.png|left|200px]]


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==Solution NMR structure of a helical bundle domain from human E3 ligase HECTD1. Northeast structural genomics consortium (NESG) target HT6305A==
The line below this paragraph, containing "STRUCTURE_2lc3", creates the "Structure Box" on the page.
<StructureSection load='2lc3' size='340' side='right'caption='[[2lc3]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2lc3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc3 OCA], [https://pdbe.org/2lc3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc3 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc3 ProSAT]</span></td></tr>
{{STRUCTURE_2lc3|  PDB=2lc3  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/HECD1_HUMAN HECD1_HUMAN] Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).


===Solution NMR structure of a helical bundle domain from human E3 ligase HECTD1. Northeast structural genomics consortium (NESG) target HT6305A===
==See Also==
 
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
[[2lc3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC3 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C.]]
[[Category: Large Structures]]
[[Category: Dhe-Paganon, S.]]
[[Category: Arrowsmith C]]
[[Category: Garcia, M.]]
[[Category: Dhe-Paganon S]]
[[Category: Houliston, S.]]
[[Category: Garcia M]]
[[Category: Lemak, A.]]
[[Category: Houliston S]]
[[Category: Montelione, G T.]]
[[Category: Lemak A]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Montelione GT]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Yee A]]
[[Category: Yee, A.]]
[[Category: Helical bundle]]
[[Category: Ligase]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]

Latest revision as of 08:41, 15 May 2024

Solution NMR structure of a helical bundle domain from human E3 ligase HECTD1. Northeast structural genomics consortium (NESG) target HT6305ASolution NMR structure of a helical bundle domain from human E3 ligase HECTD1. Northeast structural genomics consortium (NESG) target HT6305A

Structural highlights

2lc3 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HECD1_HUMAN Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity).

See Also

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