3s4t: Difference between revisions

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'''Unreleased structure'''


The entry 3s4t is ON HOLD
==Crystal structure of putative amidohydrolase-2 (EFI-target 500288)from Polaromonas sp. JS666==
 
<StructureSection load='3s4t' size='340' side='right'caption='[[3s4t]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Ramagopal, U.A., Toro, R., Girlt, J.A., Almo, S.C., Enzyme Function Initiative
== Structural highlights ==
 
<table><tr><td colspan='2'>[[3s4t]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Polaromonas_sp._JS666 Polaromonas sp. JS666]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S4T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S4T FirstGlance]. <br>
Description: Crystal structure of putative amidohydrolase-2 (EFI-target 500288)from Polaromonas sp. JS666
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s4t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s4t OCA], [https://pdbe.org/3s4t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s4t RCSB], [https://www.ebi.ac.uk/pdbsum/3s4t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s4t ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GRDC_POLSJ GRDC_POLSJ] Involved in the gamma-resorcylate (2,6-dihydroxybenzoate) catabolism (Probable). Catalyzes the reversible decarboxylation of gamma-resorcylate to resorcinol (PubMed:29283551). Also catalyzes the decarboxylation of 2,3-dihydroxybenzoate to catechol, 2,4,6-trihydroxybenzoate to benzene-1,3,5-triol, and 2,6-dihydroxy-4-methylbenzoate to 5-methylbenzene-1,3-diol (PubMed:29283551).<ref>PMID:29283551</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Polaromonas sp. JS666]]
[[Category: Almo SC]]
[[Category: Girlt JA]]
[[Category: Ramagopal UA]]
[[Category: Toro R]]

Latest revision as of 11:15, 6 December 2023

Crystal structure of putative amidohydrolase-2 (EFI-target 500288)from Polaromonas sp. JS666Crystal structure of putative amidohydrolase-2 (EFI-target 500288)from Polaromonas sp. JS666

Structural highlights

3s4t is a 8 chain structure with sequence from Polaromonas sp. JS666. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GRDC_POLSJ Involved in the gamma-resorcylate (2,6-dihydroxybenzoate) catabolism (Probable). Catalyzes the reversible decarboxylation of gamma-resorcylate to resorcinol (PubMed:29283551). Also catalyzes the decarboxylation of 2,3-dihydroxybenzoate to catechol, 2,4,6-trihydroxybenzoate to benzene-1,3,5-triol, and 2,6-dihydroxy-4-methylbenzoate to 5-methylbenzene-1,3-diol (PubMed:29283551).[1]

References

  1. ↑ Sheng X, Patskovsky Y, Vladimirova A, Bonanno JB, Almo SC, Himo F, Raushel FM. Mechanism and Structure of γ-Resorcylate Decarboxylase. Biochemistry. 2018 Jun 5;57(22):3167-3175. PMID:29283551 doi:10.1021/acs.biochem.7b01213

3s4t, resolution 1.90Å

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