3q9h: Difference between revisions

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-[[Image:3q9h.jpg|left|200px]]
-<!--
+==LVFFA segment from Alzheimer's Amyloid-Beta displayed on 42-membered macrocycle scaffold==
-The line below this paragraph, containing "STRUCTURE_3q9h", creates the "Structure Box" on the page.
+<StructureSection load='3q9h' size='340' side='right'caption='[[3q9h]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3q9h]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q9H FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BU1:1,4-BUTANEDIOL'>BU1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HAO:{[3-(HYDRAZINOCARBONYL)-4-METHOXYPHENYL]AMINO}(OXO)ACETIC+ACID'>HAO</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3q9h|  PDB=3q9h  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q9h OCA], [https://pdbe.org/3q9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q9h RCSB], [https://www.ebi.ac.uk/pdbsum/3q9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q9h ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Protein amyloid oligomers have been strongly linked to amyloid diseases and can be intermediates to amyloid fibers. beta-Sheets have been identified in amyloid oligomers. However, because of their transient and highly polymorphic properties, the details of their self-association remain elusive. Here we explore oligomer structure using a model system: macrocyclic peptides. Key amyloidogenic sequences from Abeta and tau were incorporated into macrocycles, thereby restraining them to beta-strands, but limiting the growth of the oligomers so they may crystallize and cannot fibrillate. We determined the atomic structures for four such oligomers, and all four reveal tetrameric interfaces in which beta-sheet dimers pair together by highly complementary, dry interfaces, analogous to steric zippers found in fibers, suggesting a common structure for amyloid oligomers and fibers. In amyloid fibers, the axes of the paired sheets are either parallel or antiparallel, whereas the oligomeric interfaces display a variety of sheet-to-sheet pairing angles, offering a structural explanation for the heterogeneity of amyloid oligomers.
-===LVFFA segment from Alzheimer's Amyloid-Beta displayed on 42-membered macrocycle scaffold===
+Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic beta-Sheet Mimics.,Liu C, Sawaya MR, Cheng PN, Zheng J, Nowick JS, Eisenberg D J Am Chem Soc. 2011 May 4;133(17):6736-44. Epub 2011 Apr 7. PMID:21473620<ref>PMID:21473620</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_21473620}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3q9h" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 21473620 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21473620}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-[[3q9h]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q9H OCA].
+[[Category: Cheng P]]
+[[Category: Eisenberg D]]
-==Reference==
+[[Category: Liu C]]
-<ref group="xtra">PMID:021473620</ref><references group="xtra"/>
+[[Category: Nowick JS]]
-[[Category: Cheng, P.]]
+[[Category: Sawaya MR]]
-[[Category: Eisenberg, D.]]
+[[Category: Zheng J]]
-[[Category: Liu, C.]]
-[[Category: Nowick, J S.]]
-[[Category: Sawaya, M R.]]
-[[Category: Zheng, J.]]