3ia3: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:3ia3.png|left|200px]]
-<!--
+==A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin==
-The line below this paragraph, containing "STRUCTURE_3ia3", creates the "Structure Box" on the page.
+<StructureSection load='3ia3' size='340' side='right'caption='[[3ia3]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ia3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IA3 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-{{STRUCTURE_3ia3|  PDB=3ia3  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ia3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ia3 OCA], [https://pdbe.org/3ia3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ia3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ia3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ia3 ProSAT]</span></td></tr>
+</table>
-===A cis-proline in alpha-hemoglobin stabilizing Protein directs the structural reorganization of alpha-hemoglobin===
+== Function ==
+[https://www.uniprot.org/uniprot/AHSP_HUMAN AHSP_HUMAN] Acts as a chaperone to prevent the harmful aggregation of alpha-hemoglobin during normal erythroid cell development. Specifically protects free alpha-hemoglobin from precipitation. It is predicted to modulate pathological states of alpha-hemoglobin excess such as beta-thalassemia.<ref>PMID:12066189</ref>
+== Evolutionary Conservation ==
-<!--
+[[Image:Consurf_key_small.gif|200px|right]]
-The line below this paragraph, {{ABSTRACT_PUBMED_19706593}}, adds the Publication Abstract to the page
+Check<jmol>
-(as it appears on PubMed at http://www.pubmed.gov), where 19706593 is the PubMed ID number.
+  <jmolCheckbox>
--->
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ia/3ia3_consurf.spt"</scriptWhenChecked>
-{{ABSTRACT_PUBMED_19706593}}
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
-==About this Structure==
+  </jmolCheckbox>
-[[3ia3]] is a 4 chain structure of [[Hemoglobin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IA3 OCA].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ia3 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Hemoglobin]]
+*[[Hemoglobin 3D structures|Hemoglobin 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:019706593</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Feng, L.]]
+[[Category: Large Structures]]
-[[Category: Jeffrey, P D.]]
+[[Category: Feng L]]
-[[Category: Shi, Y.]]
+[[Category: Jeffrey PD]]
-[[Category: Acetylation]]
+[[Category: Shi Y]]
-[[Category: Ahsp]]
-[[Category: Chaperone]]
-[[Category: Cis-proline]]
-[[Category: Cytoplasm]]
-[[Category: Disease mutation]]
-[[Category: Glycation]]
-[[Category: Glycoprotein]]
-[[Category: Heme]]
-[[Category: Hemoglobin]]
-[[Category: Iron]]
-[[Category: Metal-binding]]
-[[Category: Oxygen transport]]
-[[Category: Phosphoprotein]]
-[[Category: Polymorphism]]
-[[Category: Stabilization]]
-[[Category: Transport]]