Dual specificity phosphatase: Difference between revisions
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<StructureSection load='' size='350' side='right' scene='44/444621/Cv/1' caption='Human Cdc14B2 core domain (cyan) complex with tripeptide (green) and acetyl (PDB code [[1ohe]]).'> | |||
== Function == | |||
'''Dual specificity phosphatase''' or '''Dual specificity protein phosphatase''' (DUSP) is a phosphatase which dephosphorylates phosphotyrosine, phosphoserine or phosphothreonine residues<ref>PMID:19228121</ref>. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:<br /> | |||
• '''Slingshot phosphatase'''<ref>PMID:17848544</ref><br /> | |||
• '''Phosphatase of regenerating liver''' (PRL)<ref>PMID:24030100</ref><br /> | |||
• '''Cdc14''' leads to mitotic exit by dephosphorylation of targets of the protein kinase Cdk1.<ref>PMID:15568976</ref><br /> | |||
• '''Cdc25''' activates Cdk1 by its dephosphorylation.<ref>PMID:15324805</ref><br /> | |||
• '''PTEN''' (Phosphatase and TEnsin homolog) dephosphorylates phosphasitide substrates.<ref>PMID:10555148</ref> For details see [[PTEN]].<br /> | |||
• '''Myotubularin''' dephosphorylates phosphadinylinositol 3-phosphate and phosphadinylinositol (3,5)-bi-phosphate<ref>PMID:12847286</ref><br /> | |||
• '''MAPK phosphatase''' see [[MAP kinase phosphatase]]<br /> | |||
== Relevance == | |||
'''Cdc25A''' and '''Cdc25B''' are overexpressed in several types of cancers and their inhibitors are being tested as chemotherapeutic agents.<br /> | |||
'''PTEN''' gene is mutated with high frequency in a variety of human cancers.<ref>PMID:18298792</ref><br /> | |||
'''Phosphatase of regenerating liver''' is overexpressed in several types of cancers. | |||
== Disease == | |||
Myotubularin mutations are responsible for the hereditary motor disease Charcot-Marie-Tooth disease.<ref>PMID:12045210</ref> | |||
== Structural highlights == | |||
<scene name='44/444621/Cv/6'>Tripeptide binding site</scene> in human Cdc14B2 (PDB code [[1ohe]]).<ref>PMID:12853468</ref> | |||
==3D structures of dual specificity phosphatase== | |||
[[Dual specificity phosphatase 3D structures]] | |||
</StructureSection> | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||