1amo: Difference between revisions

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[[Image:1amo.png|left|200px]]


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==THREE-DIMENSIONAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE: PROTOTYPE FOR FMN-AND FAD-CONTAINING ENZYMES==
The line below this paragraph, containing "STRUCTURE_1amo", creates the "Structure Box" on the page.
<StructureSection load='1amo' size='340' side='right'caption='[[1amo]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1amo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AMO FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
{{STRUCTURE_1amo|  PDB=1amo  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1amo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1amo OCA], [https://pdbe.org/1amo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1amo RCSB], [https://www.ebi.ac.uk/pdbsum/1amo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1amo ProSAT]</span></td></tr>
 
</table>
===THREE-DIMENSIONAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE: PROTOTYPE FOR FMN-AND FAD-CONTAINING ENZYMES===
== Function ==
 
[https://www.uniprot.org/uniprot/NCPR_RAT NCPR_RAT] This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
 
== Evolutionary Conservation ==
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==About this Structure==
  </jmolCheckbox>
[[1amo]] is a 2 chain structure of [[NADPH-Cytochrome P450 Reductase]] with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AMO OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1amo ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[NADPH-Cytochrome P450 Reductase]]
*[[NADPH-Cytochrome P450 Reductase|NADPH-Cytochrome P450 Reductase]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:009237990</ref><ref group="xtra">PMID:010338023</ref><ref group="xtra">PMID:018980384</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: NADPH--hemoprotein reductase]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Kim, J J.P.]]
[[Category: Kim JJP]]
[[Category: Masters, B S.S.]]
[[Category: Masters BSS]]
[[Category: Paschke, R.]]
[[Category: Paschke R]]
[[Category: Roberts, D L.]]
[[Category: Roberts DL]]
[[Category: Shea, T M.]]
[[Category: Shea TM]]
[[Category: Wang, M.]]
[[Category: Wang M]]
[[Category: Flavoprotein]]
[[Category: Nitric oxide synthase]]
[[Category: Oxidoreductase]]
[[Category: X-ray crystallography]]

Latest revision as of 09:31, 7 February 2024

THREE-DIMENSIONAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE: PROTOTYPE FOR FMN-AND FAD-CONTAINING ENZYMESTHREE-DIMENSIONAL STRUCTURE OF NADPH-CYTOCHROME P450 REDUCTASE: PROTOTYPE FOR FMN-AND FAD-CONTAINING ENZYMES

Structural highlights

1amo is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NCPR_RAT This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1amo, resolution 2.60Å

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