3pkp: Difference between revisions

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[[Image:3pkp.png|left|200px]]


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==Q83S Variant of S. Enterica RmlA with dATP==
The line below this paragraph, containing "STRUCTURE_3pkp", creates the "Structure Box" on the page.
<StructureSection load='3pkp' size='340' side='right'caption='[[3pkp]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3pkp]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PKP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DTP:2-DEOXYADENOSINE+5-TRIPHOSPHATE'>DTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3pkp|  PDB=3pkp  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pkp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pkp OCA], [https://pdbe.org/3pkp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pkp RCSB], [https://www.ebi.ac.uk/pdbsum/3pkp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pkp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RMLA_SALTY RMLA_SALTY] Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Is also able to convert non natural substrates such as a wide array of alpha-D-hexopyranosyl, deoxy-alpha-D-glucopyranosyl, aminodeoxy-alpha-D-hexopyranosyl and acetamidodeoxy-alpha-D-hexopyranosyl phosphates to their corresponding dTDP- and UDP-nucleotide sugars.<ref>PMID:8382158</ref>


===Q83S Variant of S. Enterica RmlA with dATP===
==See Also==
 
*[[Glucose-1-phosphate thymidylyltransferase 3D structures|Glucose-1-phosphate thymidylyltransferase 3D structures]]
 
== References ==
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<references/>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_21317292}}
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
 
[[Category: Bingman CA]]
==About this Structure==
[[Category: Chang A]]
[[3pkp]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PKP OCA].
[[Category: Moretti R]]
 
[[Category: Phillips Jr GN]]
==Reference==
[[Category: Thorson JS]]
<ref group="xtra">PMID:21317292</ref><references group="xtra"/>
[[Category: Glucose-1-phosphate thymidylyltransferase]]
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
[[Category: Bingman, C A.]]
[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
[[Category: Chang, A.]]
[[Category: Moretti, R.]]
[[Category: Phillips, G N.]]
[[Category: Thorson, J S.]]

Latest revision as of 13:41, 21 February 2024

Q83S Variant of S. Enterica RmlA with dATPQ83S Variant of S. Enterica RmlA with dATP

Structural highlights

3pkp is a 8 chain structure with sequence from Salmonella enterica subsp. enterica serovar Typhimurium. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RMLA_SALTY Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Is also able to convert non natural substrates such as a wide array of alpha-D-hexopyranosyl, deoxy-alpha-D-glucopyranosyl, aminodeoxy-alpha-D-hexopyranosyl and acetamidodeoxy-alpha-D-hexopyranosyl phosphates to their corresponding dTDP- and UDP-nucleotide sugars.[1]

See Also

References

  1. ↑ Lindquist L, Kaiser R, Reeves PR, Lindberg AA. Purification, characterization and HPLC assay of Salmonella glucose-1-phosphate thymidylyl-transferase from the cloned rfbA gene. Eur J Biochem. 1993 Feb 1;211(3):763-70. PMID:8382158

3pkp, resolution 2.60Å

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