3omo: Difference between revisions

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-[[Image:3omo.png|left|200px]]
-<!--
+==Fragment-Based Design of novel Estrogen Receptor Ligands==
-The line below this paragraph, containing "STRUCTURE_3omo", creates the "Structure Box" on the page.
+<StructureSection load='3omo' size='340' side='right'caption='[[3omo]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3omo]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OMO FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WV7:2-(TRIFLUOROACETYL)-1,2,3,4-TETRAHYDROISOQUINOLIN-6-OL'>WV7</scene></td></tr>
-{{STRUCTURE_3omo|  PDB=3omo  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3omo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3omo OCA], [https://pdbe.org/3omo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3omo RCSB], [https://www.ebi.ac.uk/pdbsum/3omo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3omo ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ESR2_HUMAN ESR2_HUMAN] Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
-===Fragment-Based Design of novel Estrogen Receptor Ligands===
+==See Also==
+*[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
+__TOC__
-<!--
+</StructureSection>
-The line below this paragraph, {{ABSTRACT_PUBMED_21381753}}, adds the Publication Abstract to the page
-(as it appears on PubMed at http://www.pubmed.gov), where 21381753 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_21381753}}
-==About this Structure==
-[[3omo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OMO OCA].
-==Reference==
-<ref group="xtra">PMID:21381753</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Brunsveld, L.]]
+[[Category: Large Structures]]
-[[Category: Fuchs, S.]]
+[[Category: Brunsveld L]]
-[[Category: Moecklinghoff, S.]]
+[[Category: Dominguez Seoane M]]
-[[Category: Otterlo, W A.van.]]
+[[Category: Fuchs S]]
-[[Category: Ottmann, C.]]
+[[Category: Moecklinghoff S]]
-[[Category: Rose, R.]]
+[[Category: Ottmann C]]
-[[Category: Seoane, M Dominguez.]]
+[[Category: Rose R]]
-[[Category: Waldmann, H.]]
+[[Category: Waldmann H]]
+[[Category: Van Otterlo WA]]