2org: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2org.gif|left|200px]]<br /><applet load="2org" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2org, resolution 2.00&Aring;" />
-'''Directing Macromolecular Conformation Through Halogen Bonds'''<br />
-==Overview==
+==Directing Macromolecular Conformation Through Halogen Bonds==
-The halogen bond, a noncovalent interaction involving polarizable, chlorine, bromine, or iodine molecular substituents, is now being, exploited to control the assembly of small molecules in the design of, supramolecular complexes and new materials. We demonstrate that a halogen, bond formed between a brominated uracil and phosphate oxygen can be, engineered to direct the conformation of a biological molecule, in this, case to define the conformational isomer of a four-stranded DNA junction, when placed in direct competition against a classic hydrogen bond. As a, result, this bromine interaction is estimated to be approximately 2-5, kcal/mol stronger than the analogous hydrogen bond in this environment, depending on the geometry of the halogen bond. This study helps to, establish halogen bonding as a potential tool for the rational design and, construction of molecular materials with DNA and other biological, macromolecules.
+<StructureSection load='2org' size='340' side='right'caption='[[2org]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2org]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ORG FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2org FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2org OCA], [https://pdbe.org/2org PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2org RCSB], [https://www.ebi.ac.uk/pdbsum/2org PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2org ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The halogen bond, a noncovalent interaction involving polarizable chlorine, bromine, or iodine molecular substituents, is now being exploited to control the assembly of small molecules in the design of supramolecular complexes and new materials. We demonstrate that a halogen bond formed between a brominated uracil and phosphate oxygen can be engineered to direct the conformation of a biological molecule, in this case to define the conformational isomer of a four-stranded DNA junction when placed in direct competition against a classic hydrogen bond. As a result, this bromine interaction is estimated to be approximately 2-5 kcal/mol stronger than the analogous hydrogen bond in this environment, depending on the geometry of the halogen bond. This study helps to establish halogen bonding as a potential tool for the rational design and construction of molecular materials with DNA and other biological macromolecules.
-==About this Structure==
+Directing macromolecular conformation through halogen bonds.,Voth AR, Hays FA, Ho PS Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:17379665<ref>PMID:17379665</ref>
-ORG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ORG OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Directing macromolecular conformation through halogen bonds., Voth AR, Hays FA, Ho PS, Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6188-93. Epub 2007 Mar 22. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17379665 17379665]
+</div>
-[[Category: Protein complex]]
+<div class="pdbe-citations 2org" style="background-color:#fffaf0;"></div>
-[[Category: Hays, F.A.]]
+== References ==
-[[Category: Ho, P.S.]]
+<references/>
-[[Category: Voth, A.R.]]
+__TOC__
-[[Category: dna holliday junction]]
+</StructureSection>
-[[Category: halogen bond]]
+[[Category: Large Structures]]
+[[Category: Hays FA]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:15:16 2008''
+[[Category: Ho PS]]
+[[Category: Voth AR]]