3raf: Difference between revisions

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-'''Unreleased structure'''
-The entry 3raf is ON HOLD
+==Quinazolinedione-DNA cleavage complex of type IV topoisomerase from S. pneumoniae==
+<StructureSection load='3raf' size='340' side='right'caption='[[3raf]], [[Resolution|resolution]] 3.24&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3raf]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RAF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RAF FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.24&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDQ:3-AMINO-7-{(3R)-3-[(1S)-1-AMINOETHYL]PYRROLIDIN-1-YL}-1-CYCLOPROPYL-6-FLUORO-8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE'>PDQ</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3raf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3raf OCA], [https://pdbe.org/3raf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3raf RCSB], [https://www.ebi.ac.uk/pdbsum/3raf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3raf ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>
-Authors: Laponogov, I., Pan, X.-S., Veselkov, D.A., McAuley, K.E., Fisher, L.M., Sanderson, M.R.
+==See Also==
+*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
-Description: Quinazolinedione-DNA cleavage complex of type IV topoisomerase from S. pneumoniae
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Streptococcus pneumoniae]]
+[[Category: Fisher LM]]
+[[Category: Laponogov I]]
+[[Category: McAuley KE]]
+[[Category: Pan X-S]]
+[[Category: Sanderson MR]]
+[[Category: Veselkov DA]]