2yf0: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
New page: '''Unreleased structure''' The entry 2yf0 is ON HOLD until sometime in the future Authors: Moche, M., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, ...
 
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
'''Unreleased structure'''


The entry 2yf0 is ON HOLD  until sometime in the future
==Human Myotubularin related protein 6 (MTMR6)==
<StructureSection load='2yf0' size='340' side='right'caption='[[2yf0]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2yf0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YF0 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yf0 OCA], [https://pdbe.org/2yf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yf0 RCSB], [https://www.ebi.ac.uk/pdbsum/2yf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yf0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MTMR6_HUMAN MTMR6_HUMAN] Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.<ref>PMID:15831468</ref> <ref>PMID:16847315</ref>


Authors: Moche, M., Tresaugues, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, I., Karlberg, T., Kotenyova, T., Kouznetsova, E., Nyman, T., Persson, C., Schuler, H., Schutz, P., Siponen, M.I., Thorsell, A.G., VanDenBerg, S., Wahlberg, E., Weigelt, J., Welin, M., Nordlund, P.
==See Also==
 
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
Description: Human Myotubularin related protein 6 (MTMR6)
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Berglund H]]
[[Category: Bountra C]]
[[Category: Collins R]]
[[Category: Edwards AM]]
[[Category: Flodin S]]
[[Category: Flores A]]
[[Category: Graslund S]]
[[Category: Hammarstrom M]]
[[Category: Johansson I]]
[[Category: Karlberg T]]
[[Category: Kotenyova T]]
[[Category: Kouznetsova E]]
[[Category: Moche M]]
[[Category: Nordlund P]]
[[Category: Nyman T]]
[[Category: Persson C]]
[[Category: Schuler H]]
[[Category: Schutz P]]
[[Category: Siponen MI]]
[[Category: Thorsell AG]]
[[Category: Tresaugues L]]
[[Category: VanDenBerg S]]
[[Category: Wahlberg E]]
[[Category: Weigelt J]]
[[Category: Welin M]]

Latest revision as of 13:51, 20 December 2023

Human Myotubularin related protein 6 (MTMR6)Human Myotubularin related protein 6 (MTMR6)

Structural highlights

2yf0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.65Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MTMR6_HUMAN Phosphatase that acts on lipids with a phosphoinositol headgroup. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4+ T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3 phosphatase. Negatively regulates proliferation of reactivated CD4+ T-cells.[1] [2]

See Also

References

  1. ↑ Srivastava S, Li Z, Lin L, Liu G, Ko K, Coetzee WA, Skolnik EY. The phosphatidylinositol 3-phosphate phosphatase myotubularin- related protein 6 (MTMR6) is a negative regulator of the Ca2+-activated K+ channel KCa3.1. Mol Cell Biol. 2005 May;25(9):3630-8. PMID:15831468 doi:http://dx.doi.org/10.1128/MCB.25.9.3630-3638.2005
  2. ↑ Srivastava S, Ko K, Choudhury P, Li Z, Johnson AK, Nadkarni V, Unutmaz D, Coetzee WA, Skolnik EY. Phosphatidylinositol-3 phosphatase myotubularin-related protein 6 negatively regulates CD4 T cells. Mol Cell Biol. 2006 Aug;26(15):5595-602. PMID:16847315 doi:http://dx.doi.org/10.1128/MCB.00352-06

2yf0, resolution 2.65Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2yf0&oldid=3996045"