2iho: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-[[Image:2iho.jpg|left|200px]]<br /><applet load="2iho" size="350" color="white" frame="true" align="right" spinBox="true"
-caption="2iho, resolution 2.41&Aring;" />
-'''Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc'''<br />
-==Overview==
+==Crystal structure of MOA, a lectin from the mushroom Marasmius oreades in complex with the trisaccharide Gal(1,3)Gal(1,4)GlcNAc==
-MOA, a lectin from the mushroom Marasmius oreades, is one of the few, reagents that specifically agglutinate blood group B erythrocytes., Further, it is the only lectin known to have exclusive specificity for, Galalpha(1,3)Gal-containing sugar epitopes, which are antigens that pose a, severe barrier to animal-to-human organ transplantation. We describe here, the structure of MOA at 2.4 A resolution, in complex with the linear, trisaccharide Galalpha(1,3)Galbeta(1,4)GlcNAc. The structure is dimeric, with two distinct domains per protomer: the N-terminal lectin module, adopts a ricinB/beta-trefoil fold and contains three putative, carbohydrate-binding sites, while the C-terminal domain serves as a, dimerization interface. This latter domain, which has an unknown function, reveals a novel fold with intriguing conservation of an active site cleft., A number of indications suggest that MOA may have an enzymatic function in, addition to the sugar-binding properties.
+<StructureSection load='2iho' size='340' side='right'caption='[[2iho]], [[Resolution|resolution]] 2.41&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2iho]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Marasmius_oreades Marasmius oreades]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IHO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IHO FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.41&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2iho FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iho OCA], [https://pdbe.org/2iho PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2iho RCSB], [https://www.ebi.ac.uk/pdbsum/2iho PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2iho ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q8X123_9AGAR Q8X123_9AGAR]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ih/2iho_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2iho ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-IHO is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Marasmius_oreades Marasmius oreades]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IHO OCA].
+*[[Agglutinin 3D structures|Agglutinin 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Crystal structure of the marasmius oreades mushroom lectin in complex with a xenotransplantation epitope., Grahn E, Askarieh G, Holmner A, Tateno H, Winter HC, Goldstein IJ, Krengel U, J Mol Biol. 2007 Jun 8;369(3):710-21. Epub 2007 Mar 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17442345 17442345]
+[[Category: Large Structures]]
 [[Category: Marasmius oreades]]
-[[Category: Single protein]]
+[[Category: Askarieh G]]
-[[Category: Askarieh, G.]]
+[[Category: Goldstein IJ]]
-[[Category: Goldstein, I.J.]]
+[[Category: Grahn E]]
-[[Category: Grahn, E.]]
+[[Category: Holmner A]]
-[[Category: Holmner, A.]]
+[[Category: Krengel U]]
-[[Category: Krengel, U.]]
+[[Category: Tateno H]]
-[[Category: Tateno, H.]]
+[[Category: Winter HC]]
-[[Category: Winter, H.C.]]
-[[Category: beta-trefoil]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:03:30 2008''