Colicin 6: Difference between revisions
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==Mechanism of uptake== | ==Mechanism of uptake== | ||
The receptor binding domain of the colicin binds to the outer membrane receptor Tsx on the target cell; it is a constitutively expressed protein parasitised by the colicin. The translocation domain then recruits proteins from the [[Ton]] system to translocate the protein across the membrane and into the cytoplasm. | |||
==Killing Activities== | ==Killing Activities== | ||
Colicin 6 has [[Pore Formation]] activities, whereby it inserts into the membrane of the targeted cell from the cytoplasm, and forms a pore. This causes depolarisation of the membrane, which is needed for the cell to synthesise ATP. Once this process is halted, the cell cannot survive and so dies. | |||