Sandbox 80: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Pat McQuaid, Student

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 This is an antiviral drug used to treat HIV by inhibiting proteases in the virus. This inhibition causes the spread of the virus to decrease significantly. The <scene name='Sandbox_80/Protease/1'>protease</scene> is an enzyme that the virus uses to produce the proteins necessary to assemble more viruses.
-The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to <scene name='Sandbox_80/Ac_1/1'>active site 1</scene> of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles.
+The common name for saqinavir is fortovase. It functions as peptide-like analogue that binds to <scene name='Sandbox_80/Ac_1/1'>active site 1</scene> of the protein and causes inhibition by preventing the protease from cleaving polyproteins which in turn causes the virus to create non-infectious virus particles. This drug is often used in combination with other HIV medications to produce a more potent effect.
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-{{STRUCTURE_3oxc |  PDB=3oxc  |  SCENE=  }}
+==Protein and Drug interations==
+intermolecular forces that cause the drug to bind in the active site of the protease are prodominantly H-bonds to
+<scene name='Sandbox_80/Hydrophilic/1'>hydrophilic groups</scene>. The carboxylic acid group in the <scene name='Sandbox_80/Asp_25/1'>Aspartic Acid</scene> residue 25 binds with the hydroxyl group of Saquinavir.
-==Protein and Drug interations==
-intermolecular forces
-attraction
 ==References==
 http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000973
 http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=60934&loc=ec_rcs#pharmaction