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==Crystal structure of the second glutaredoxin domain of human TXNL2== | |||
<StructureSection load='2yan' size='340' side='right'caption='[[2yan]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2yan]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YAN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yan OCA], [https://pdbe.org/2yan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yan RCSB], [https://www.ebi.ac.uk/pdbsum/2yan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yan ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GLRX3_HUMAN GLRX3_HUMAN] Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Allerston C]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Bountra C]] | |||
[[Category: Cocking R]] | |||
[[Category: Edwards A]] | |||
[[Category: Johansson C]] | |||
[[Category: Krojer T]] | |||
[[Category: Muniz JRC]] | |||
[[Category: Oppermann U]] | |||
[[Category: Vollmar M]] | |||
[[Category: Weigelt J]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 11:11, 23 August 2023
Crystal structure of the second glutaredoxin domain of human TXNL2Crystal structure of the second glutaredoxin domain of human TXNL2
Structural highlights
FunctionGLRX3_HUMAN Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. |
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