2ehg: Difference between revisions
New page: left|200px<br /><applet load="2ehg" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ehg, resolution 1.60Å" /> '''Crystal structure of... |
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== | ==Crystal structure of hyperthermophilic archaeal RNase HI== | ||
<StructureSection load='2ehg' size='340' side='right'caption='[[2ehg]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
[ | == Structural highlights == | ||
[ | <table><tr><td colspan='2'>[[2ehg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sulfurisphaera_tokodaii_str._7 Sulfurisphaera tokodaii str. 7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EHG FirstGlance]. <br> | ||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ehg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ehg OCA], [https://pdbe.org/2ehg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ehg RCSB], [https://www.ebi.ac.uk/pdbsum/2ehg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ehg ProSAT]</span></td></tr> | ||
[ | </table> | ||
[[ | == Function == | ||
[https://www.uniprot.org/uniprot/RNH_SULTO RNH_SULTO] Nuclease that specifically degrades the RNA of RNA-DNA hybrids. Endonucleolytically removes RNA primers from the Okazaki fragments of lagging strand synthesis on its own. In the presence of Mn(2+) or Co(2+) can also cleave an RNA-RNA hybrid; the dsRNase activity is 10- 100-fold lower than RNase H activity. Complements the temperature-sensitive phenotype of an E.coli double rnhA/rnhB (RNase H) disruption mutant.<ref>PMID:15520465</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
[ | Check<jmol> | ||
[[ | <jmolCheckbox> | ||
[ | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eh/2ehg_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ehg ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Sulfurisphaera tokodaii str. 7]] | |||
[[Category: Chon H]] | |||
[[Category: Kanaya S]] | |||
[[Category: Koga Y]] | |||
[[Category: Takano K]] | |||
[[Category: You DJ]] | |||
