2xoi: Difference between revisions

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-[[Image:2xoi.jpg|left|200px]]
-<!--
+==Functional and Structural Analyses of N-Acylsulfonamide-Linked Dinucleoside Inhibitors of Ribonuclease A==
-The line below this paragraph, containing "STRUCTURE_2xoi", creates the "Structure Box" on the page.
+<StructureSection load='2xoi' size='340' side='right'caption='[[2xoi]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2xoi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XOI FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SFB:(2S,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-N-[[(2S,3S,4R,5R)-5-(2,4-DIOXOPYRIMIDIN-1-YL)-4-HYDROXY-2-(HYDROXYMETHYL)OXOLAN-3-YL]METHYLSULFONYL]-3,4-DIHYDROXY-OXOLANE-2-CARBOXAMIDE'>SFB</scene></td></tr>
-{{STRUCTURE_2xoi|  PDB=2xoi  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xoi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xoi OCA], [https://pdbe.org/2xoi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xoi RCSB], [https://www.ebi.ac.uk/pdbsum/2xoi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xoi ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RNAS1_BOVIN RNAS1_BOVIN] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA.<ref>PMID:7479688</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Molecular probes are useful for both studying and controlling the functions of enzymes and other proteins. The most useful probes have high affinity for their target, along with small size and resistance to degradation. Here, we report on new surrogates for nucleic acids that fulfill these criteria. Isosteres in which phosphoryl [R-O-P(O(2) (-) )-O-R'] groups are replaced with N-acylsulfonamidyl [R-C(O)-N(-) -S(O(2) )-R'] or sulfonimidyl [R-S(O(2) )-N(-) -S(O(2) )-R'] groups increase the number of nonbridging oxygens from two (phosphoryl) to three (N-acylsulfonamidyl) or four (sulfonimidyl). Six such isosteres were found to be more potent inhibitors of catalysis by bovine pancreatic RNase A than are parent compounds containing phosphoryl groups. The atomic structures of two RNase A.N-acylsulfonamide complexes were determined at high resolution by X-ray crystallography. The N-acylsulfonamidyl groups were observed to form more hydrogen bonds with active site residues than did the phosphoryl groups in analogous complexes. These data encourage the further development and use of N-acylsulfonamides and sulfonimides as antagonists of nucleic acid-binding proteins.
-===FUNCTIONAL AND STRUCTURAL ANALYSES OF N-ACYLSULFONAMIDE-LINKED DINUCLEOSIDE INHIBITORS OF RIBONUCLEASE A===
+Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A.,Thiyagarajan N, Smith BD, Raines RT, Acharya KR FEBS J. 2010 Dec 4. doi: 10.1111/j.1742-4658.2010.07976.x. PMID:21205197<ref>PMID:21205197</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2xoi" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21205197}}, adds the Publication Abstract to the page
+*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21205197 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21205197}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[2xoi]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XOI OCA].
-==Reference==
-<ref group="xtra">PMID:21205197</ref><references group="xtra"/>
 [[Category: Bos taurus]]
-[[Category: Pancreatic ribonuclease]]
+[[Category: Large Structures]]
-[[Category: Acharya, K R.]]
+[[Category: Acharya KR]]
-[[Category: Raines, R T.]]
+[[Category: Raines RT]]
-[[Category: Smith, B D.]]
+[[Category: Smith BD]]
-[[Category: Thiyagarajan, N.]]
+[[Category: Thiyagarajan N]]