2x89: Difference between revisions

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-[[Image:2x89.jpg|left|200px]]
-<!--
+==Structure of the Beta2_microglobulin involved in amyloidogenesis==
-The line below this paragraph, containing "STRUCTURE_2x89", creates the "Structure Box" on the page.
+<StructureSection load='2x89' size='340' side='right'caption='[[2x89]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2x89]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X89 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2X89 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.16&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2x89 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x89 OCA], [https://pdbe.org/2x89 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2x89 RCSB], [https://www.ebi.ac.uk/pdbsum/2x89 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2x89 ProSAT]</span></td></tr>
-{{STRUCTURE_2x89|  PDB=2x89  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A2KD59_LAMGL A2KD59_LAMGL]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Atomic-level structural investigation of the key conformational intermediates of amyloidogenesis remains a challenge. Here we demonstrate the utility of nanobodies to trap and characterize intermediates of beta2-microglobulin (beta2m) amyloidogenesis by X-ray crystallography. For this purpose, we selected five single domain antibodies that block the fibrillogenesis of a proteolytic amyloidogenic fragment of beta2m (DeltaN6beta2m). The crystal structure of DeltaN6beta2m in complex with one of these nanobodies (Nb24) identifies domain swapping as a plausible mechanism of self-association of this amyloidogenic protein. In the swapped dimer, two extended hinge loops-corresponding to the heptapetide NHVTLSQ that forms amyloid in isolation-are unmasked and fold into a new two-stranded antiparallel beta-sheet. The beta-strands of this sheet are prone to self-associate and stack perpendicular to the direction of the strands to build large intermolecular beta-sheets that run parallel to the axis of growing oligomers, providing an elongation mechanism by self-templated growth.
-===STRUCTURE OF THE BETA2_MICROGLOBULIN INVOLVED IN AMYLOIDOGENESIS===
+Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic {beta}2-microglobulin variant.,Domanska K, Vanderhaegen S, Srinivasan V, Pardon E, Dupeux F, Marquez JA, Giorgetti S, Stoppini M, Wyns L, Bellotti V, Steyaert J Proc Natl Acad Sci U S A. 2011 Jan 10. PMID:21220305<ref>PMID:21220305</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2x89" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21220305}}, adds the Publication Abstract to the page
+*[[Antibody 3D structures|Antibody 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21220305 is the PubMed ID number.
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
--->
+*[[3D structures of non-human antibody|3D structures of non-human antibody]]
-{{ABSTRACT_PUBMED_21220305}}
+== References ==
+<references/>
-==About this Structure==
+__TOC__
-[[2x89]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X89 OCA].
+</StructureSection>
+[[Category: Camelus dromedarius]]
-==Reference==
-<ref group="xtra">PMID:21220305</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Bellotti, V.]]
+[[Category: Large Structures]]
-[[Category: Domanska, K.]]
+[[Category: Bellotti V]]
-[[Category: Marquez, J A.]]
+[[Category: Domanska K]]
-[[Category: Pardon, E.]]
+[[Category: Marquez JA]]
-[[Category: Srinivasan, V.]]
+[[Category: Pardon E]]
-[[Category: Steyaert, J.]]
+[[Category: Srinivasan V]]
-[[Category: Vanderhaegen, S.]]
+[[Category: Steyaert J]]
-[[Category: Wyns, L.]]
+[[Category: Vanderhaegen S]]
+[[Category: Wyns L]]