3alz: Difference between revisions

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-[[Image:3alz.jpg|left|200px]]
-<!--
+==Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I)==
-The line below this paragraph, containing "STRUCTURE_3alz", creates the "Structure Box" on the page.
+<StructureSection load='3alz' size='340' side='right'caption='[[3alz]], [[Resolution|resolution]] 4.51&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3alz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Measles_virus_strain_Edmonston-B Measles virus strain Edmonston-B] and [https://en.wikipedia.org/wiki/Saguinus_oedipus Saguinus oedipus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ALZ FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.515&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-{{STRUCTURE_3alz|  PDB=3alz  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3alz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3alz OCA], [https://pdbe.org/3alz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3alz RCSB], [https://www.ebi.ac.uk/pdbsum/3alz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3alz ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HEMA_MEASE HEMA_MEASE] Attaches the virus to cell receptors and thereby initiating infection. Binding of H protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion. May use human CD46 and/or SLAMF1 as receptors for viral entry into the cell. The high degree of interaction between H and MCP/CD46 results in down-regulation of the latter from the surface of infected cells, rendering them more sensitive to c3b-mediated complement lysis.<ref>PMID:9811778</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Measles virus, a major cause of childhood morbidity and mortality worldwide, predominantly infects immune cells using signaling lymphocyte activation molecule (SLAM) as a cellular receptor. Here we present crystal structures of measles virus hemagglutinin (MV-H), the receptor-binding glycoprotein, in complex with SLAM. The MV-H head domain binds to a beta-sheet of the membrane-distal ectodomain of SLAM using the side of its beta-propeller fold. This is distinct from attachment proteins of other paramyxoviruses that bind receptors using the top of their beta-propeller. The structure provides templates for antiviral drug design, an explanation for the effectiveness of the measles virus vaccine, and a model of the homophilic SLAM-SLAM interaction involved in immune modulations. Notably, the crystal structures obtained show two forms of the MV-H-SLAM tetrameric assembly (dimer of dimers), which may have implications for the mechanism of fusion triggering.
-===Crystal structure of the measles virus hemagglutinin bound to its cellular receptor SLAM (Form I)===
+Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM.,Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, Yanagi Y Nat Struct Mol Biol. 2011 Feb;18(2):135-41. Epub 2011 Jan 9. PMID:21217702<ref>PMID:21217702</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3alz" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[3alz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Measles_virus Measles virus] and [http://en.wikipedia.org/wiki/Saguinus_oedipus Saguinus oedipus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ALZ OCA].
+*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
-[[Category: Measles virus]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Measles virus strain Edmonston-B]]
 [[Category: Saguinus oedipus]]
-[[Category: Hashiguchi, T.]]
+[[Category: Hashiguchi T]]
-[[Category: Kamishikiryo, J.]]
+[[Category: Kamishikiryo J]]
-[[Category: Kubota, M.]]
+[[Category: Kubota M]]
-[[Category: Maenaka, K.]]
+[[Category: Maenaka K]]
-[[Category: Maita, N.]]
+[[Category: Maita N]]
-[[Category: Ose, T.]]
+[[Category: Ose T]]
-[[Category: Yanagi, Y.]]
+[[Category: Yanagi Y]]