3n0t: Difference between revisions

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[[Image:3n0t.png|left|200px]]


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==Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A==
The line below this paragraph, containing "STRUCTURE_3n0t", creates the "Structure Box" on the page.
<StructureSection load='3n0t' size='340' side='right'caption='[[3n0t]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3n0t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N0T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OPY:(3S)-4-OXO-4-PIPERIDIN-1-YLBUTANE-1,3-DIAMINE'>OPY</scene></td></tr>
{{STRUCTURE_3n0t|  PDB=3n0t  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0t OCA], [https://pdbe.org/3n0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n0t RCSB], [https://www.ebi.ac.uk/pdbsum/3n0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n0t ProSAT]</span></td></tr>
 
</table>
===Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A===
== Function ==
 
[https://www.uniprot.org/uniprot/DPP2_HUMAN DPP2_HUMAN] Plays an important role in the degradation of some oligopeptides.<ref>PMID:15487984</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
[[3n0t]] is a 4 chain structure of [[Dipeptidyl peptidase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0T OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n0/3n0t_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n0t ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Dipeptidyl peptidase]]
*[[Dipeptidyl peptidase 3D structures|Dipeptidyl peptidase 3D structures]]
[[Category: Dipeptidyl-peptidase II]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bochkarev, A.]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C.]]
[[Category: Bochkarev A]]
[[Category: Cossar, D.]]
[[Category: Bountra C]]
[[Category: Crombet, L.]]
[[Category: Cossar D]]
[[Category: Dobrovetsky, E.]]
[[Category: Crombet L]]
[[Category: Edwards, A M.]]
[[Category: Dobrovetsky E]]
[[Category: Haffner, C.]]
[[Category: Edwards AM]]
[[Category: Hassell, A.]]
[[Category: Haffner C]]
[[Category: Khutoreskaya, G.]]
[[Category: Hassell A]]
[[Category: Pagannon, S.]]
[[Category: Khutoreskaya G]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Pagannon S]]
[[Category: Seitova, A.]]
[[Category: Seitova A]]
[[Category: Shewchuk, L.]]
[[Category: Shewchuk L]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Aminopeptidase]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Cytoplasmic vesicle]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Lysosome]]
[[Category: Protease]]
[[Category: Serine protease]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
[[Category: Zymogen]]

Latest revision as of 09:00, 17 October 2024

Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826AHuman dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A

Structural highlights

3n0t is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.45Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPP2_HUMAN Plays an important role in the degradation of some oligopeptides.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Maes MB, Lambeir AM, Gilany K, Senten K, Van der Veken P, Leiting B, Augustyns K, Scharpe S, De Meester I. Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7). Biochem J. 2005 Mar 1;386(Pt 2):315-24. PMID:15487984 doi:http://dx.doi.org/10.1042/BJ20041156

3n0t, resolution 2.45Å

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