3m08: Difference between revisions

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[[Image:3m08.png|left|200px]]


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==Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1==
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<StructureSection load='3m08' size='340' side='right'caption='[[3m08]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3m08]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M08 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M08 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.014&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=RAR:5-(3,4-DIMETHOXY-5-{(1E)-3-OXO-3-[(1S)-1-PROPYLPHTHALAZIN-2(1H)-YL]PROP-1-EN-1-YL}BENZYL)PYRIMIDINE-2,4-DIAMINE'>RAR</scene></td></tr>
{{STRUCTURE_3m08|  PDB=3m08  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m08 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m08 OCA], [https://pdbe.org/3m08 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m08 RCSB], [https://www.ebi.ac.uk/pdbsum/3m08 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m08 ProSAT]</span></td></tr>
 
</table>
===Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1===
== Function ==
 
[https://www.uniprot.org/uniprot/DYR_STAAU DYR_STAAU] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m0/3m08_consurf.spt"</scriptWhenChecked>
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[3m08]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M08 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m08 ConSurf].
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==See Also==
==See Also==
*[[Dihydrofolate reductase]]
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:20606069</ref><references group="xtra"/>
[[Category: Large Structures]]
[[Category: Dihydrofolate reductase]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Barrow, W W.]]
[[Category: Barrow WW]]
[[Category: Bourne, C R.]]
[[Category: Bourne CR]]
[[Category: Antibiotic resistance]]
[[Category: Antimicrobial]]
[[Category: Dhfr]]
[[Category: Folate]]
[[Category: Nadp]]
[[Category: One-carbon metabolism]]
[[Category: Oxidoreductases']]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Latest revision as of 13:23, 21 February 2024

Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1Wild Type Dihydrofolate Reductase from Staphylococcus aureus with inhibitor RAB1

Structural highlights

3m08 is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.014Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DYR_STAAU Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3m08, resolution 2.01Å

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