2qw9: Difference between revisions

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[[Image:2qw9.png|left|200px]]


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==Crystal structure of bovine hsc70 (1-394aa)in the apo state==
The line below this paragraph, containing "STRUCTURE_2qw9", creates the "Structure Box" on the page.
<StructureSection load='2qw9' size='340' side='right'caption='[[2qw9]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2qw9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QW9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QW9 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_2qw9|  PDB=2qw9  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qw9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qw9 OCA], [https://pdbe.org/2qw9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qw9 RCSB], [https://www.ebi.ac.uk/pdbsum/2qw9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qw9 ProSAT]</span></td></tr>
 
</table>
===Crystal structure of bovine hsc70 (1-394aa)in the apo state===
== Function ==
 
[https://www.uniprot.org/uniprot/HSP7C_BOVIN HSP7C_BOVIN] Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
The line below this paragraph, {{ABSTRACT_PUBMED_17996706}}, adds the Publication Abstract to the page
Check<jmol>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qw/2qw9_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_17996706}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[2qw9]] is a 2 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QW9 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qw9 ConSurf].
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==See Also==
==See Also==
*[[Heat Shock Proteins]]
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:17996706</ref><references group="xtra"/>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Hinck, A P.]]
[[Category: Large Structures]]
[[Category: Jiang, J.]]
[[Category: Hinck AP]]
[[Category: Lafer, E M.]]
[[Category: Jiang J]]
[[Category: Maes, E G.]]
[[Category: Lafer EM]]
[[Category: Sousa, R.]]
[[Category: Maes EG]]
[[Category: Taylor, A B.]]
[[Category: Sousa R]]
[[Category: Wang, L.]]
[[Category: Taylor AB]]
[[Category: Atp-binding]]
[[Category: Wang L]]
[[Category: Chaperone]]
[[Category: Cytoplasm]]
[[Category: Nucleotide-binding]]
[[Category: Nucleus]]
[[Category: Phosphorylation]]
[[Category: Stress response]]

Latest revision as of 12:18, 21 February 2024

Crystal structure of bovine hsc70 (1-394aa)in the apo stateCrystal structure of bovine hsc70 (1-394aa)in the apo state

Structural highlights

2qw9 is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.85Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

HSP7C_BOVIN Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

2qw9, resolution 1.85Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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