2pbc: Difference between revisions

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OCA

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-[[Image:2pbc.png|left|200px]]
-<!--
+==FK506-binding protein 2==
-The line below this paragraph, containing "STRUCTURE_2pbc", creates the "Structure Box" on the page.
+<StructureSection load='2pbc' size='340' side='right'caption='[[2pbc]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2pbc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PBC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
-{{STRUCTURE_2pbc|  PDB=2pbc  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pbc OCA], [https://pdbe.org/2pbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pbc RCSB], [https://www.ebi.ac.uk/pdbsum/2pbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pbc ProSAT]</span></td></tr>
+</table>
-===FK506-binding protein 2===
+== Function ==
+[https://www.uniprot.org/uniprot/FKBP2_HUMAN FKBP2_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
+== Evolutionary Conservation ==
-==About this Structure==
+[[Image:Consurf_key_small.gif|200px|right]]
-[[2pbc]] is a 4 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PBC OCA].
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pb/2pbc_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pbc ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Cyclophilin]]
+*[[FKBP 3D structures|FKBP 3D structures]]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Peptidylprolyl isomerase]]
+[[Category: Large Structures]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Bochkarev, A.]]
+[[Category: Bochkarev A]]
-[[Category: Butler-Cole, C.]]
+[[Category: Butler-Cole C]]
-[[Category: Davis, T.]]
+[[Category: Davis T]]
-[[Category: Dhe-Paganon, S.]]
+[[Category: Dhe-Paganon S]]
-[[Category: Edwards, A M.]]
+[[Category: Edwards AM]]
-[[Category: Neculai, D.]]
+[[Category: Neculai D]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Sicheri F]]
-[[Category: Sicheri, F.]]
+[[Category: Sundstrom M]]
-[[Category: Sundstrom, M.]]
+[[Category: Walker JR]]
-[[Category: Walker, J R.]]
+[[Category: Weigelt J]]
-[[Category: Weigelt, J.]]
-[[Category: Endoplasmic reticulum]]
-[[Category: Isomerase]]
-[[Category: Polymorphism]]
-[[Category: Rotamase]]
-[[Category: Sgc]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]