3kex: Difference between revisions

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-[[Image:3kex.png|left|200px]]
-<!--
+==Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)==
-The line below this paragraph, containing "STRUCTURE_3kex", creates the "Structure Box" on the page.
+<StructureSection load='3kex' size='340' side='right'caption='[[3kex]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3kex]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KEX FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.797&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-{{STRUCTURE_3kex|  PDB=3kex  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kex FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kex OCA], [https://pdbe.org/3kex PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kex RCSB], [https://www.ebi.ac.uk/pdbsum/3kex PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kex ProSAT]</span></td></tr>
+</table>
-===Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)===
+== Disease ==
+[https://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN] Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:[https://omim.org/entry/607598 607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.<ref>PMID:17701904</ref>
+== Function ==
-<!--
+[https://www.uniprot.org/uniprot/ERBB3_HUMAN ERBB3_HUMAN] Binds and is activated by neuregulins and NTAK.<ref>PMID:15358134</ref>
-The line below this paragraph, {{ABSTRACT_PUBMED_20007378}}, adds the Publication Abstract to the page
+== Evolutionary Conservation ==
-(as it appears on PubMed at http://www.pubmed.gov), where 20007378 is the PubMed ID number.
+[[Image:Consurf_key_small.gif|200px|right]]
--->
+Check<jmol>
-{{ABSTRACT_PUBMED_20007378}}
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ke/3kex_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-[[3kex]] is a 2 chain structure of [[Epidermal Growth Factor Receptor]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KEX OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kex ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Epidermal Growth Factor Receptor]]
+*[[Epidermal growth factor receptor 3D structures|Epidermal growth factor receptor 3D structures]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:20007378</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Receptor protein-tyrosine kinase]]
+[[Category: Large Structures]]
-[[Category: Cao, X.]]
+[[Category: Cao X]]
-[[Category: Jura, N.]]
+[[Category: Jura N]]
-[[Category: Kuriyan, J.]]
+[[Category: Kuriyan J]]
-[[Category: Shan, Y.]]
+[[Category: Shan Y]]
-[[Category: Shaw, D E.]]
+[[Category: Shaw DE]]
-[[Category: Atp-binding]]
-[[Category: Cell membrane]]
-[[Category: Erbb3]]
-[[Category: Her3]]
-[[Category: Inactive kinase]]
-[[Category: Kinase]]
-[[Category: Kinase domain]]
-[[Category: Membrane]]
-[[Category: Nucleotide-binding]]
-[[Category: Phosphoprotein]]
-[[Category: Receptor]]
-[[Category: Transferase]]
-[[Category: Tyrosine-protein kinase]]