3hr4: Difference between revisions

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[[Image:3hr4.png|left|200px]]


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==Human iNOS Reductase and Calmodulin Complex==
The line below this paragraph, containing "STRUCTURE_3hr4", creates the "Structure Box" on the page.
<StructureSection load='3hr4' size='340' side='right'caption='[[3hr4]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3hr4]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3HR4 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene></td></tr>
{{STRUCTURE_3hr4|  PDB=3hr4  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3hr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3hr4 OCA], [https://pdbe.org/3hr4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3hr4 RCSB], [https://www.ebi.ac.uk/pdbsum/3hr4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3hr4 ProSAT]</span></td></tr>
 
</table>
===Human iNOS Reductase and Calmodulin Complex===
== Function ==
 
[https://www.uniprot.org/uniprot/NOS2_HUMAN NOS2_HUMAN] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
[[3hr4]] is a 8 chain structure of [[Calmodulin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3HR4 OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hr/3hr4_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3hr4 ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Calmodulin]]
*[[Calmodulin 3D structures|Calmodulin 3D structures]]
*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Nitric-oxide synthase]]
[[Category: Large Structures]]
[[Category: Iyanaki, T.]]
[[Category: Iyanaki T]]
[[Category: Kim, J J.K.]]
[[Category: Kim JJK]]
[[Category: Misra, I.]]
[[Category: Misra I]]
[[Category: Xia, C.]]
[[Category: Xia C]]
[[Category: Acetylation]]
[[Category: Alternative splicing]]
[[Category: Calcium]]
[[Category: Calmodulin]]
[[Category: Calmodulin-binding]]
[[Category: Fad]]
[[Category: Fmn]]
[[Category: Heme]]
[[Category: Inducible nitric oxide synthase]]
[[Category: Ino]]
[[Category: Iron]]
[[Category: Isopeptide bond]]
[[Category: Metal-binding]]
[[Category: Methylation]]
[[Category: Nadp]]
[[Category: No]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase/metal binding protein complex]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Ubl conjugation]]
[[Category: Zinc]]

Latest revision as of 10:27, 6 September 2023

Human iNOS Reductase and Calmodulin ComplexHuman iNOS Reductase and Calmodulin Complex

Structural highlights

3hr4 is a 8 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NOS2_HUMAN Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3hr4, resolution 2.50Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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